*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : XH5624200
CHEMICAL NAME           : Theophylline,
                          7-(3-(4-(p-fluorobenzoyl)piperidino)-2-hydroxypropyl)
                          -, hydrate
CAS REGISTRY NUMBER     : 86071-01-4
LAST UPDATED            : 199406
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C22-H26-F-N5-O4.H2-O
MOLECULAR WEIGHT        : 461.55
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   *   7-(3-(4-(p-Fluorobenzoyl)-piperidino)-2-hydroxy-propyl)-theophyllin-hydr
     at
   * 7-(3-(4-(p-Fluorobenzoyl)piperidino)-2-hydroxypropyl)theophylline hydrate
   * Sgd 145 80
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >1 gm/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - ptosis
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - ataxia
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 34,1,1984
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 135 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - ptosis
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - ataxia
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 34,1,1984
 
                            *** END OF RECORD ***