*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : XH6495000
CHEMICAL NAME           : Theophylline, 7-(2-((3-pyridylmethyl)amino)ethyl)-,
                          nicotinate
CAS REGISTRY NUMBER     : 10058-07-8
LAST UPDATED            : 198609
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C21-H23-N7-O4
MOLECULAR WEIGHT        : 437.51
WISWESSER LINE NOTATION : T56 BN DN FNVNVJ F1 H1 B2M1- CT6NJ &T6NJ CVQ
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * ES 902
   * 7-(beta-3'-Picolylaminoaethyl)theophyllin-nicotinat
   * 7-(2-(Piridil)-metilammino-etil)-teofillino nicotinato
   * 7-(2-((3-Pyridylmethyl)amino)ethyl)theophylline nicotinate
   * Teonicon
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 3700 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GMITAB Gazzetta Medica Italiana.  (Turin, Italy)  V.95-142, 1936-83.
   Volume(issue)/page/year: 132,36,1973
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2300 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GMITAB Gazzetta Medica Italiana.  (Turin, Italy)  V.95-142, 1936-83.
   Volume(issue)/page/year: 132,36,1973
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2530 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PAHEAA Pharmaceutica Acta Helvetiae.  (Schweizerische Apothekerzeitung,
   Postfach 3006, CH3000 Bern, 7, Switzerland)  V.1-    1926-
   Volume(issue)/page/year: 48,133,1973
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 470 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PAHEAA Pharmaceutica Acta Helvetiae.  (Schweizerische Apothekerzeitung,
   Postfach 3006, CH3000 Bern, 7, Switzerland)  V.1-    1926-
   Volume(issue)/page/year: 48,133,1973
 
                            *** END OF RECORD ***