*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : XH9250000
CHEMICAL NAME           : 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid,
                          3,3-dimethyl-7-oxo-6-(((((2-oxo-1-
                          imidazolidinyl)carbonyl)amino)phenylacetyl)amino)-,
                          monosodium salt, (2S-(2-alpha,5-alpha,6-beta(S*)))-
CAS REGISTRY NUMBER     : 37091-65-9
LAST UPDATED            : 199609
DATA ITEMS CITED        : 6
MOLECULAR FORMULA       : C20-H22-N5-O6-S.Na
MOLECULAR WEIGHT        : 483.52
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Azlocillin sodium
   * Monosodium azlocillin
   * Securopen
   * Sodium azlocillin
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1793 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - tremor
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   AMBIEH Antibiotiki i Meditsinskaya Biotekhnologiya.  Antibiotics and Medical
   Biotechnology. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.30-V.32,
   1985-1987  Volume(issue)/page/year: 32,453,1987
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 6690 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - tremor
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   AMBIEH Antibiotiki i Meditsinskaya Biotekhnologiya.  Antibiotics and Medical
   Biotechnology. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.30-V.32,
   1985-1987  Volume(issue)/page/year: 32,453,1987
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 5065 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - excitement
REFERENCE :
   AMBIEH Antibiotiki i Meditsinskaya Biotekhnologiya.  Antibiotics and Medical
   Biotechnology. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.30-V.32,
   1985-1987  Volume(issue)/page/year: 32,453,1987
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 15420 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - tremor
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   AMBIEH Antibiotiki i Meditsinskaya Biotekhnologiya.  Antibiotics and Medical
   Biotechnology. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.30-V.32,
   1985-1987  Volume(issue)/page/year: 32,453,1987
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 27 gm/kg/4W-I
TOXIC EFFECTS :
   Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
   Biochemical - Enzyme inhibition, induction, or change in blood or tissue
   levels - phosphatases
   Biochemical - Enzyme inhibition, induction, or change in blood or tissue
   levels - transaminases
REFERENCE :
   AMBIEH Antibiotiki i Meditsinskaya Biotekhnologiya.  Antibiotics and Medical
   Biotechnology. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.30-V.32,
   1985-1987  Volume(issue)/page/year: 32,453,1987

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - X5282
       No. of Facilities: 7 (estimated)
       No. of Industries: 1
       No. of Occupations: 2
       No. of Employees: 307 (estimated)
       No. of Female Employees: 251 (estimated)

 
                            *** END OF RECORD ***