*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : XH9425000 CHEMICAL NAME : 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6- (2-phenylacetamido)-, compd. with N,N'-dibenzylethylenediamine (2:1) CAS REGISTRY NUMBER : 1538-09-6 OTHER CAS REGISTRY NOS. : 12705-12-3 LAST UPDATED : 199707 DATA ITEMS CITED : 5 MOLECULAR FORMULA : C32-H36-N4-O8-S2.C16-H20-N2 MOLECULAR WEIGHT : 909.22 WISWESSER LINE NOTATION : T45 ANV ESTJ CMV1R& F F GVQ & 2 &622 COMPOUND DESCRIPTOR : Drug Reproductive Effector SYNONYMS/TRADE NAMES : * Beacillin * Benzacillin * Benzapen * Benzathine benzylpenicillin * Benzathine penicillin * Benzathine penicillin G * Benzethacil * Benzylpenicillin benzathine * Benzylpenicillin dibenzylethylenediamine salt * Bica-penicillin * Bicillin * Cepacilina * Cillenta * Debecillin * Debecylina * Diamine penicillin * Diaminocillina * Dibencil * Dibencillin * N,N'-Dibenzylethylenediamine bis(benzyl penicillin) * Dibenzylethylenediamine-di-penicillin G * N,N'-Dibenzylethylenediamine, compounded with penicillin G (1:2) * N,N'-Dibenzylethylenediamine salt of benzylpenicillin * Durabiotic * Dura-penita * Duropenin * Ethylenediamine, N,N'-dibenzyl-, compd. with penicillin G (1:2) * Extencilline * Extenicilline * Lentocillin * Lentopenil * Leomypen * Longacilina * Longicil * Megacillin suspension * Moldamin * NCI-C56100 * Neolin * Penadur * Penadur L-A * Pendepon * Pen-Di-Ben * Penditan * Penduran * Penicillin G, benzathine * Penicillin G, compd. with N,N'-dibenzylethylenediamine (2:1) * Penicillin G salt of N,N'-dibenzylethylenediamine * Penidural * Penidure * Permapen * Tardocillin * Vicin * Wycillina *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 2 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,774,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 460 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Lungs, Thorax, or Respiration - dyspnea REFERENCE : ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC) V.1-12, 1951-62. For publisher information, see CLMEA3. Volume(issue)/page/year: 4,633,1954 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Parenteral SPECIES OBSERVED : Rodent - rat DOSE : 22905 ug/kg SEX/DURATION : female 4 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) REFERENCE : BEXBAN Bulletin of Experimental Biology and Medicine (English Translation). Translation of BEBMAE. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.41- 1956- Volume(issue)/page/year: 82,1076,1976 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - T1268 No. of Facilities: 49 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 1896 (estimated) No. of Female Employees: 921 (estimated) *** STATUS IN U.S. *** EPA TSCA Section 8(b) CHEMICAL INVENTORY *** END OF RECORD ***