*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : XH9425000
CHEMICAL NAME           : 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid,
                          3,3-dimethyl-7-oxo-6- (2-phenylacetamido)-, compd.
                          with N,N'-dibenzylethylenediamine (2:1)
CAS REGISTRY NUMBER     : 1538-09-6
OTHER CAS REGISTRY NOS. : 12705-12-3
LAST UPDATED            : 199707
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C32-H36-N4-O8-S2.C16-H20-N2
MOLECULAR WEIGHT        : 909.22
WISWESSER LINE NOTATION : T45 ANV ESTJ CMV1R& F F GVQ & 2 &622
COMPOUND DESCRIPTOR     : Drug
                          Reproductive Effector
SYNONYMS/TRADE NAMES :
   * Beacillin
   * Benzacillin
   * Benzapen
   * Benzathine benzylpenicillin
   * Benzathine penicillin
   * Benzathine penicillin G
   * Benzethacil
   * Benzylpenicillin benzathine
   * Benzylpenicillin dibenzylethylenediamine salt
   * Bica-penicillin
   * Bicillin
   * Cepacilina
   * Cillenta
   * Debecillin
   * Debecylina
   * Diamine penicillin
   * Diaminocillina
   * Dibencil
   * Dibencillin
   * N,N'-Dibenzylethylenediamine bis(benzyl penicillin)
   * Dibenzylethylenediamine-di-penicillin G
   * N,N'-Dibenzylethylenediamine, compounded with penicillin G (1:2)
   * N,N'-Dibenzylethylenediamine salt of benzylpenicillin
   * Durabiotic
   * Dura-penita
   * Duropenin
   * Ethylenediamine, N,N'-dibenzyl-, compd. with penicillin G (1:2)
   * Extencilline
   * Extenicilline
   * Lentocillin
   * Lentopenil
   * Leomypen
   * Longacilina
   * Longicil
   * Megacillin suspension
   * Moldamin
   * NCI-C56100
   * Neolin
   * Penadur
   * Penadur L-A
   * Pendepon
   * Pen-Di-Ben
   * Penditan
   * Penduran
   * Penicillin G, benzathine
   * Penicillin G, compd. with N,N'-dibenzylethylenediamine (2:1)
   * Penicillin G salt of N,N'-dibenzylethylenediamine
   * Penidural
   * Penidure
   * Permapen
   * Tardocillin
   * Vicin
   * Wycillina
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,774,1982
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 460 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - excitement
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   ANTCAO Antibiotics and Chemotherapy (Washington, DC).  (Washington, DC)
   V.1-12, 1951-62.  For publisher information, see CLMEA3.
   Volume(issue)/page/year: 4,633,1954
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Parenteral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 22905 ug/kg
SEX/DURATION            : female 4 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
REFERENCE :
   BEXBAN Bulletin of Experimental Biology and Medicine (English Translation).
   Translation of BEBMAE. (Plenum Pub. Corp., 233 Spring St., New York, NY
   10013)  V.41-    1956-  Volume(issue)/page/year: 82,1076,1976

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - T1268
       No. of Facilities: 49 (estimated)
       No. of Industries: 1
       No. of Occupations: 2
       No. of Employees: 1896 (estimated)
       No. of Female Employees: 921 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY

 
                            *** END OF RECORD ***