*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : XH9437000
CHEMICAL NAME : 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid,
3,3-dimethyl-7-oxo-6-(2- phenylacetamido)-, compd.
with 2-(diethylamino)ethyl p-aminobenzoate (1:1)
CAS REGISTRY NUMBER : 54-35-3
LAST UPDATED : 199707
DATA ITEMS CITED : 12
MOLECULAR FORMULA : C16-H18-N2-O4-S.C13-H20-N2-O2
MOLECULAR WEIGHT : 570.77
SYNONYMS/TRADE NAMES :
* Benzylpenicillin novocaine salt
* Benzylpenicillin procaine
* Depocillin
* Duphapen
* Hostacillin
* Hydracillin
* Jenacillin O
* Micro-Pen
* Nopcaine
* Penicillin G procaine
* Penzal N 300
* Procaine penicillin G
* Procaine benzylpenicillinate
* Retardillin
* Vetspen
* Vitablend
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >2 gm/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - other changes
REFERENCE :
ABANAE Antibiotics Annual. (New York, NY) 1953-60. For publisher
information, see AMACCQ. Volume(issue)/page/year: 3,534,1955/1956
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 420 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - other changes
REFERENCE :
ABANAE Antibiotics Annual. (New York, NY) 1953-60. For publisher
information, see AMACCQ. Volume(issue)/page/year: 3,534,1955/1956
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >2 gm/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - other changes
REFERENCE :
ABANAE Antibiotics Annual. (New York, NY) 1953-60. For publisher
information, see AMACCQ. Volume(issue)/page/year: 3,534,1955/1956
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : >2 gm/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - other changes
REFERENCE :
ABANAE Antibiotics Annual. (New York, NY) 1953-60. For publisher
information, see AMACCQ. Volume(issue)/page/year: 3,534,1955/1956
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 371 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - other changes
REFERENCE :
ABANAE Antibiotics Annual. (New York, NY) 1953-60. For publisher
information, see AMACCQ. Volume(issue)/page/year: 3,534,1955/1956
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 4 gm/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex)
Behavioral - tremor
Behavioral - ataxia
REFERENCE :
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon
Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho,
Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year:
55,23,1959
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : >2 gm/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - other changes
REFERENCE :
ABANAE Antibiotics Annual. (New York, NY) 1953-60. For publisher
information, see AMACCQ. Volume(issue)/page/year: 3,534,1955/1956
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 518 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - other changes
REFERENCE :
ABANAE Antibiotics Annual. (New York, NY) 1953-60. For publisher
information, see AMACCQ. Volume(issue)/page/year: 3,534,1955/1956
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 1194 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - other changes
REFERENCE :
ABANAE Antibiotics Annual. (New York, NY) 1953-60. For publisher
information, see AMACCQ. Volume(issue)/page/year: 3,534,1955/1956
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - M2729
No. of Facilities: 71 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 357 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - M2729
No. of Facilities: 851 (estimated)
No. of Industries: 2
No. of Occupations: 7
No. of Employees: 7402 (estimated)
No. of Female Employees: 3182 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
*** END OF RECORD ***