*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : XI0185000
CHEMICAL NAME           : 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid,
                          6-(((hexahydro-1H-azepin-1-yl)methylene)
                          amino)-3,3-dimethyl-7-oxo-, (+)-
CAS REGISTRY NUMBER     : 32887-01-7
OTHER CAS REGISTRY NOS. : 51556-89-9
                          73937-07-2
                          79580-20-4
LAST UPDATED            : 199512
DATA ITEMS CITED        : 7
MOLECULAR FORMULA       : C15-H23-N3-O3-S
MOLECULAR WEIGHT        : 325.47
WISWESSER LINE NOTATION : T45 ANV ESTJ F1 F1 GVQ CNU1- AT7NTJ
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Amdinocillin
   * FL 1060
   * Hexacillin
   * 6-((Hexahydro-1H-azepin-1-yl)methyleneamino)penicillanic acid
   * Mecilinamo
   * Mecillinam
   * Penicillin HX
   * Ro 10-9070
   * Selexidin
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >10 gm/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - ataxia
REFERENCE :
   EKFMA7 Eksperimental'naya i Klinicheskaya Farmakoterapiya.  (Izdatel'stvo
   Zinantne, Riga, USSR) No.1-    1970-  Volume(issue)/page/year: 9,91,1980
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >4 gm/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - ataxia
REFERENCE :
   EKFMA7 Eksperimental'naya i Klinicheskaya Farmakoterapiya.  (Izdatel'stvo
   Zinantne, Riga, USSR) No.1-    1970-  Volume(issue)/page/year: 9,91,1980
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >1500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   MDACAP Medicamentos de Actualidad.  (J.R. Prous, S.A., Apartado de Correos
   540, 08080 Barcelona, Spain)  V.1-    1965-  Volume(issue)/page/year:
   16,191,1980
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >20 gm/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - effect, not otherwise specified
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   EKFMA7 Eksperimental'naya i Klinicheskaya Farmakoterapiya.  (Izdatel'stvo
   Zinantne, Riga, USSR) No.1-    1970-  Volume(issue)/page/year: 9,91,1980
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 3500 mg/kg
TOXIC EFFECTS :
   Blood - other changes
REFERENCE :
   EKFMA7 Eksperimental'naya i Klinicheskaya Farmakoterapiya.  (Izdatel'stvo
   Zinantne, Riga, USSR) No.1-    1970-  Volume(issue)/page/year: 9,91,1980
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   MDACAP Medicamentos de Actualidad.  (J.R. Prous, S.A., Apartado de Correos
   540, 08080 Barcelona, Spain)  V.1-    1965-  Volume(issue)/page/year:
   16,191,1980
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 130 gm/kg/26W-I
TOXIC EFFECTS :
   Blood - normocytic anemia
   Liver - changes in liver weight
   Related to Chronic Data - changes in testicular weight
REFERENCE :
   EKFMA7 Eksperimental'naya i Klinicheskaya Farmakoterapiya.  (Izdatel'stvo
   Zinantne, Riga, USSR) No.1-    1970-  Volume(issue)/page/year: 9,91,1980
 
                            *** END OF RECORD ***