*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : XI0192000
CHEMICAL NAME           : 4-Thia-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic
                          acid, 3-(((aminocarbonyl)oxy)methyl)-6-
                          (1-hydroxyethyl)-7-oxo-, (acetyloxy)methyl ester,
                          (5R-(5-alpha,6-alpha(R*)))-
CAS REGISTRY NUMBER     : 87238-52-6
BEILSTEIN REFERENCE NO. : 4723315
LAST UPDATED            : 199612
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C13-H16-N2-O8-S
MOLECULAR WEIGHT        : 360.37
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Acetoxymethyl  
   (5R,6S)-2-carbamoyloxymethyl-6-((1R)-hydroxyethyl)-2-penem-3-carboxylate
   * FCE 22891
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >5 gm/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   JACHDX Journal of Antimicrobial Chemotherapy.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802)  V.1-    1975-  Volume(issue)/page/year:
   23(Suppl C),129,1989
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 4363 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   JACHDX Journal of Antimicrobial Chemotherapy.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802)  V.1-    1975-  Volume(issue)/page/year:
   23(Suppl C),129,1989
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 91 gm/kg/26W-I
TOXIC EFFECTS :
   Kidney, Ureter, Bladder - urine volume decreased
   Kidney, Ureter, Bladder - other changes in urine composition
   Biochemical - Metabolism (Intermediary) - lipids including transport
REFERENCE :
   TOPADD Toxicologic Pathology.  (c/o Dr. F.A. de la Iglesia, Warner-Lambert
   Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106) V.6(3/4)- 
     1978-  Volume(issue)/page/year: 23,34,1995
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 42 gm/kg/2W-I
TOXIC EFFECTS :
   Related to Chronic Data - death
REFERENCE :
   JACHDX Journal of Antimicrobial Chemotherapy.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802)  V.1-    1975-  Volume(issue)/page/year:
   23(Suppl C),129,1989
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Primate - monkey
DOSE/DURATION           : 73 gm/kg/26W-I
TOXIC EFFECTS :
   Kidney, Ureter, Bladder - other changes
   Kidney, Ureter, Bladder - changes in bladder weight
REFERENCE :
   TOPADD Toxicologic Pathology.  (c/o Dr. F.A. de la Iglesia, Warner-Lambert
   Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106) V.6(3/4)- 
     1978-  Volume(issue)/page/year: 23,34,1995
 
                            *** END OF RECORD ***