*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : XI0196000
CHEMICAL NAME           : 4-Thia-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic
                          acid, 3-(((aminocarbonyl)oxy)methyl)-6-
                          (1-hydroxyethyl)-7-oxo-, monosodium salt,
                          (5R-(5-alpha,6-alpha(R*)))-
CAS REGISTRY NUMBER     : 84845-58-9
LAST UPDATED            : 199606
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C10-H11-N2-O6-S.Na
MOLECULAR WEIGHT        : 310.28
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * FCE 22101
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2 gm/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   JACHDX Journal of Antimicrobial Chemotherapy.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802)  V.1-    1975-  Volume(issue)/page/year:
   23(Suppl C),129,1989
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 3872 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   JACHDX Journal of Antimicrobial Chemotherapy.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802)  V.1-    1975-  Volume(issue)/page/year:
   23(Suppl C),129,1989
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 28 gm/kg/4W-I
TOXIC EFFECTS :
   Kidney, Ureter, Bladder - other changes
   Related to Chronic Data - death
REFERENCE :
   JACHDX Journal of Antimicrobial Chemotherapy.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802)  V.1-    1975-  Volume(issue)/page/year:
   23(Suppl C),129,1989
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 33600 mg/kg/8W-I
TOXIC EFFECTS :
   Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
   JACHDX Journal of Antimicrobial Chemotherapy.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802)  V.1-    1975-  Volume(issue)/page/year:
   23(Suppl C),129,1989
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Primate - monkey
DOSE/DURATION           : 54600 mg/kg/13W-I
TOXIC EFFECTS :
   Gastrointestinal - nausea or vomiting
   Blood - normocytic anemia
   Related to Chronic Data - death
REFERENCE :
   JACHDX Journal of Antimicrobial Chemotherapy.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802)  V.1-    1975-  Volume(issue)/page/year:
   23(Suppl C),129,1989
 
                            *** END OF RECORD ***