*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : XI0367225
CHEMICAL NAME           : 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic
                          acid, 7-((2-(2-amino-4-thiazolyl)-4-carboxy-
                          1-oxo-2-butenyl)amino)-8-oxo-, disodium salt,
                          (6R-(6-alpha,7-beta(E)))-
CAS REGISTRY NUMBER     : 97547-76-7
LAST UPDATED            : 199509
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C15-H12-N4-O6-S2.2Na
MOLECULAR WEIGHT        : 454.41
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * 7432-S-trans sodium salt
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >10 gm/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - muscle weakness
   Gastrointestinal - hypermotility, diarrhea
REFERENCE :
   NKRZAZ Chemotherapy (Tokyo).  (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki,
   Shinagawa-Ku, Tokyo 141, Japan)  V.1-    1953- Volume(issue)/page/year:
   37(Suppl 1),804,1994
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 3977 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - dyspnea
   Gastrointestinal - other changes
REFERENCE :
   NKRZAZ Chemotherapy (Tokyo).  (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki,
   Shinagawa-Ku, Tokyo 141, Japan)  V.1-    1953- Volume(issue)/page/year:
   37(Suppl 1),804,1994
 
                            *** END OF RECORD ***