*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : XI0383700
CHEMICAL NAME           : 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic
                          acid, 7-((hydroxyphenylacetyl)amino)-3-
                          (((1-methyl-1H-tetrazol-5-yl)thio)methyl)-8-oxo-,
                          (6R-(6-alpha,7-beta(R*)))-
CAS REGISTRY NUMBER     : 34444-01-4
BEILSTEIN REFERENCE NO. : 0598510
LAST UPDATED            : 199612
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C18-H18-N6-O5-S2
MOLECULAR WEIGHT        : 462.54
COMPOUND DESCRIPTOR     : Reproductive Effector
SYNONYMS/TRADE NAMES :
   * Cefadole
   * Cefamandol
   * Cefamandole
   * L-Cefamandole
   * Cephadole
   * Cephamandole
   * Mandokef
 
                       *** HEALTH HAZARD DATA ***
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 15 gm/kg/5D-I
TOXIC EFFECTS :
   Kidney, Ureter, Bladder - other changes in urine composition
   Biochemical - Enzyme inhibition, induction, or change in blood or tissue
   levels - dehydrogenases
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 30,660,1980
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 30 gm/kg
SEX/DURATION            : male 30 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
   FAATDF Fundamental and Applied Toxicology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1981-  Volume(issue)/page/year:
   8,280,1987

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - X3194
       No. of Facilities: 299 (estimated)
       No. of Industries: 1
       No. of Occupations: 5
       No. of Employees: 16094 (estimated)
       No. of Female Employees: 13604 (estimated)

 
                            *** END OF RECORD ***