*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : XI3600000 CHEMICAL NAME : 1,3,4-Thiadiazole, 2-amino-5-(5-nitro-2-furyl)- CAS REGISTRY NUMBER : 712-68-5 BEILSTEIN REFERENCE NO. : 0616834 LAST UPDATED : 199612 DATA ITEMS CITED : 7 MOLECULAR FORMULA : C6-H4-N4-O3-S MOLECULAR WEIGHT : 212.20 WISWESSER LINE NOTATION : T5OTJ BNW E- ET5NN DSJ CZ COMPOUND DESCRIPTOR : Tumorigen Drug Mutagen SYNONYMS/TRADE NAMES : * 2-Amino-5-(5-nitro-2-furyl)-1,3,4-thiadiazole * 5-Amino-2-(5-nitro-2-furyl)-1,3,4-thiadiazole * ASA-140 * Furidazina * Furidiazina * Furidiazine * NF-475 * 5-(5-Nitro-2-furanyl)-1,3,4-thiadiazol-2-amine * 2-(5-Nitro-2-furyl)-5-amino-1,3,4-thiadiazole * 5-(5-Nitro-2-furyl)-2-amino-1,3,4-thiadiazole * Ph/778 * 1,3,4-Thiadiazol-2-amine, 5-(5-nitro-2-furanyl)- * Thiafur * Tiafur * Triafur *** HEALTH HAZARD DATA *** ** TUMORIGENIC DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 6 gm/kg/46W-I TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors Skin and Appendages - tumors REFERENCE : JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8. Volume(issue)/page/year: 54,841,1975 TYPE OF TEST : TD - Toxic dose (other than lowest) ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 2240 mg/kg/32W-C TOXIC EFFECTS : Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors Reproductive - Tumorigenic effects - uterine tumors REFERENCE : FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87. Volume(issue)/page/year: 29,817,1970 *** REVIEWS *** IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 7,143,1974 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 7,143,1974 IARC Cancer Review:Group 2B IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 TOXICOLOGY REVIEW CCSUDL Carcinogenesis--A Comprehensive Survey. (Raven Press, 1185 Ave. of the Americas, New York, NY 10036) V.1- 1976- Volume(issue)/page/year: 4,171,1978 *** STATUS IN U.S. *** EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat *** END OF RECORD ***