*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : XI3600000
CHEMICAL NAME           : 1,3,4-Thiadiazole, 2-amino-5-(5-nitro-2-furyl)-
CAS REGISTRY NUMBER     : 712-68-5
BEILSTEIN REFERENCE NO. : 0616834
LAST UPDATED            : 199612
DATA ITEMS CITED        : 7
MOLECULAR FORMULA       : C6-H4-N4-O3-S
MOLECULAR WEIGHT        : 212.20
WISWESSER LINE NOTATION : T5OTJ BNW E- ET5NN DSJ CZ
COMPOUND DESCRIPTOR     : Tumorigen
                          Drug
                          Mutagen
SYNONYMS/TRADE NAMES :
   * 2-Amino-5-(5-nitro-2-furyl)-1,3,4-thiadiazole
   * 5-Amino-2-(5-nitro-2-furyl)-1,3,4-thiadiazole
   * ASA-140
   * Furidazina
   * Furidiazina
   * Furidiazine
   * NF-475
   * 5-(5-Nitro-2-furanyl)-1,3,4-thiadiazol-2-amine
   * 2-(5-Nitro-2-furyl)-5-amino-1,3,4-thiadiazole
   * 5-(5-Nitro-2-furyl)-2-amino-1,3,4-thiadiazole
   * Ph/778
   * 1,3,4-Thiadiazol-2-amine, 5-(5-nitro-2-furanyl)-
   * Thiafur
   * Tiafur
   * Triafur
 
                       *** HEALTH HAZARD DATA ***
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 6 gm/kg/46W-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Gastrointestinal - tumors
   Skin and Appendages - tumors
REFERENCE :
   JNCIAM Journal of the National Cancer Institute.  (Washington, DC)  V.1-60,
   1940-78.  For publisher information, see JJIND8.  Volume(issue)/page/year:
   54,841,1975
 
TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2240 mg/kg/32W-C
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
   Reproductive - Tumorigenic effects - uterine tumors
REFERENCE :
   FEPRA7 Federation Proceedings, Federation of American Societies for
   Experimental Biology. (Bethesda, MD)  V.1-46, 1942-87.
   Volume(issue)/page/year: 29,817,1970

                              *** REVIEWS ***
 
   IARC Cancer Review:Animal Sufficient Evidence
   IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
   to Man.  (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
   V.1-    1972-  Volume(issue)/page/year: 7,143,1974

   IARC Cancer Review:Human No Adequate Data
   IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
   to Man.  (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
   V.1-    1972-  Volume(issue)/page/year: 7,143,1974

   IARC Cancer Review:Group 2B
   IMSUDL IARC Monographs, Supplement.  (WHO Publications Centre USA, 49
   Sheridan Ave., Albany, NY 12210)  No.1-    1979-  Volume(issue)/page/year:
   7,56,1987

   TOXICOLOGY REVIEW
   CCSUDL Carcinogenesis--A Comprehensive Survey.  (Raven Press, 1185 Ave. of
   the Americas, New York, NY 10036)  V.1-    1976-  Volume(issue)/page/year:
   4,171,1978

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat

 
                            *** END OF RECORD ***