*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : XI3654000 CHEMICAL NAME : 1,3,4-Thiadiazole, 2-amino-5-(2-thienyl)-, hydrochloride, hydrate CAS REGISTRY NUMBER : 102367-70-4 LAST UPDATED : 199512 DATA ITEMS CITED : 3 MOLECULAR FORMULA : C6-H5-N3-S2.Cl-H.H2-O MOLECULAR WEIGHT : 237.74 WISWESSER LINE NOTATION : T5NN DSJ CZ E- BT5SJ &GH &QH COMPOUND DESCRIPTOR : Drug SYNONYMS/TRADE NAMES : * 2-Amino-5-(2-thienyl)-1,3,4-thiadiazole hydrochloride hydrate * 2-Amino-5-(2-tienil)-1,3,4-tiadiazolo cloridrato idrato * L 1458 *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 374 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - lacrimation Behavioral - tremor Lungs, Thorax, or Respiration - cyanosis REFERENCE : FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 13,187,1958 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 21420 mg/kg/17W-I TOXIC EFFECTS : Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death REFERENCE : BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 13,357,1958 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 2800 mg/kg/2W-I TOXIC EFFECTS : Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Autonomic Nervous System - other (direct) parasympathomimetic Blood - changes in cell count (unspecified) REFERENCE : BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 13,357,1958 *** END OF RECORD ***