*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : XI3900000
CHEMICAL NAME           : 1,3,4-Thiadiazole, 2-ethylamino-
CAS REGISTRY NUMBER     : 13275-68-8
BEILSTEIN REFERENCE NO. : 0110762
REFERENCE               : 4-27-00-08053 (Beilstein Handbook Reference)
LAST UPDATED            : 199701
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C4-H7-N3-S
MOLECULAR WEIGHT        : 129.20
WISWESSER LINE NOTATION : T5NN DSJ CM2
COMPOUND DESCRIPTOR     : Drug
                          Reproductive Effector
SYNONYMS/TRADE NAMES :
   * CL 19217 4090L 7-5525
   * 2-Ethylaminothiadiazole
   * 2-Ethylamino-1,3,4-thiadiazole
   * N-Ethyl-1,3,4-thiadiazol-2-amine
   * NSC 4730
   * 1,3,4-Thiadiazol-2-amine, N-ethyl-
   * X 197
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CPCHAO Clinical Proceedings of the Children's Hospital of the District of
   Columbia.  (Washington, DC) V.1-27, 1971.  For publisher information, see
   CPNMAQ.  Volume(issue)/page/year: 18,307,1962
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JHMJAX Johns Hopkins Medical Journal.  (Baltimore, MD)  V.120-151, 1967-82.
   Discontinued.  Volume(issue)/page/year: 130,95,1972
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 795 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NCISP* National Cancer Institute Screening Program Data Summary,
   Developmental Therapeutics Program. (Bethesda, MD 20205)
   Volume(issue)/page/year: JAN1986
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 150 mg/kg
SEX/DURATION            : female 10-11 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including nose and tongue)
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   JHMJAX Johns Hopkins Medical Journal.  (Baltimore, MD)  V.120-151, 1967-82.
   Discontinued.  Volume(issue)/page/year: 130,95,1972

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY

 
                            *** END OF RECORD ***