*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : XJ0776350
CHEMICAL NAME           : 4H-1,3-Thiazine, 5,6-dihydro-2-(2,6-xylidino)-,
                          monohydrochloride
CAS REGISTRY NUMBER     : 23076-35-9
LAST UPDATED            : 199609
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C12-H16-N2-S.Cl-H
MOLECULAR WEIGHT        : 256.82
WISWESSER LINE NOTATION : T6N CS AUTJ BMR B1 F1 &GH
COMPOUND DESCRIPTOR     : Drug
                          Human
SYNONYMS/TRADE NAMES :
   * BAY-VA 1470
   * BAY 1470 hydrochloride
   * Celactal
   * 5,6-Dihydro-2-(2,6-xylidino)-4H-1,3-thiazine monohydrochloride
   * 2-(2,6-Dimethylphenylamino)-4H-5,6-dihydro-1,3-thiazine hydrochloride
   * Rompun
   * 4H-1,3-Thiazin-2-amine, N-(2,6-dimethylphenyl)-5,6-dihydro-,  
   monoydrochloride
   * Xylazine chloride
   * Xylazine hydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 14 mg/kg
TOXIC EFFECTS :
   Behavioral - coma
   Cardiac - EKG changes not diagnostic of specified effects
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   CTOXAO Clinical Toxicology.  (New York, NY)  V.1-18, 1968-81.  For publisher
   information, see JTCTDW.  Volume(issue)/page/year: 15,281,1979
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 109 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ZYYZEW Zhongguo Yaolixue Yu Dulixue Zazhi.  (Chinese Pharmacological
   Society, 27 Tai-Ping Road, Beijing 100850, China)  V.1-    1986-
   Volume(issue)/page/year: 9,96,1995
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 47 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CTOXAO Clinical Toxicology.  (New York, NY)  V.1-18, 1968-81.  For publisher
   information, see JTCTDW.  Volume(issue)/page/year: 15,281,1979
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 10 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   VHTODE Veterinary and Human Toxicology.  (American College of Veterinary and
   Comparative Toxicology, Publication Office, Comparative Toxicology,
   Manhattan, KS 66506)  V.19-    1977-  Volume(issue)/page/year: 24,410,1982
 
                            *** END OF RECORD ***