*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : XJ4025000
CHEMICAL NAME           : Thiazole, 2,4-diamino-5-phenyl-, hydrochloride
CAS REGISTRY NUMBER     : 942-31-4
LAST UPDATED            : 199803
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C9-H9-N3-S.Cl-H
MOLECULAR WEIGHT        : 227.73
WISWESSER LINE NOTATION : T5N CSJ BZ DR& EZ &GH
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Amifenatsol hydrochloride
   * Amiphenazole hydrochloride
   * Amphenazole hydrochloride
   * Amphisol hydrochloride
   * Daftazol hydrochloride
   * Daptazile hydrochloride
   * Daptazole hydrochloride
   * 2,4-Diamino 5-phenylthiazol chlorhydrate
   * 2,4-Diamino-5-phenylthiazole hydrochloride
   * 2,4-Diamino-5-phenylthiazole monohydrochloride
   * Fenamizol hydrochloride
   * Phenamizole hydrochloride
   * 5-Phenyl-2,4-thiazolediamine monohydrochloride
   * Thiazole, 2,4-diamino-5-phenyl-, monohydrochloride
   * 2,4-Thiazolediamine, 5-phenyl-, monohydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 300 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and
   D.H. Efron, Washington, DC, 1972  Volume(issue)/page/year: -,201,1972
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 330 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PCJOAU Pharmaceutical Chemistry Journal (English Translation).  Translation
   of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013)  No.1-
   1967-  Volume(issue)/page/year: 7,489,1973
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 159 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - effect, not otherwise specified
   Behavioral - muscle contraction or spasticity
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   FRZKAP Farmatsevtichnii Zhurnal (Kiev).  (V/O Mezhdunarodnaya Kniga, 113095
   Moscow, USSR) V.3-    1930-  Volume(issue)/page/year: 26(5),20,1971
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 310 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPPMAB Journal of Pharmacy and Pharmacology.  (Pharmaceutical Soc. of Great
   Britain, 1 Lambeth High St., London SEI 7JN, UK)  V.1-    1949-
   Volume(issue)/page/year: 21,668,1969
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 144 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 110,465,1957
 
                            *** END OF RECORD ***