*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : XJ5131750
CHEMICAL NAME           : delta(sup 2,alpha)-Thiazolidineacetic acid,
                          3-ethyl-4-oxo-5-piperidino-, ethyl ester, (Z)-
CAS REGISTRY NUMBER     : 63250-48-6
LAST UPDATED            : 199312
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C14-H22-N2-O3-S
MOLECULAR WEIGHT        : 298.44
WISWESSER LINE NOTATION : T5SYNV EHJ BU1VO2 C2 E- AT6NTJ -Z
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Acetic acid, (3-ethyl-4-oxo-5-(1-piperidinyl)-2-thiazolidinylidene)-,  
   ethyl ester, (Z)-
   *   Z-(3-Aethyl-4-oxo-5-piperidino-thiazolidin-2-yliden)-essigsaure-aethyles
     ter
   * Ethyl 3-ethyl-4-oxo-5-piperidino-delta(sup 2,alpha)-thiazolidineacetate
   * Ethyl (Z)-(3-ethyl-4-oxo-5-piperidinothiazolidin-2-ylidene)acetate
   * cis-2-(3-Ethyl-4-oxo-5-piperidino-2-thiazolidinylidene)acetic acid
   * (3-Ethyl-4-oxo-5-(1-piperidinyl)-2-thiazolidinylidene)acetic acid ethyl  
   ester
   * Go 919
   * Piprozolin
   * Piprozoline
   * Probilin
   * W 3699
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 3256 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 27,467,1977
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1070 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 27,467,1977
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 200 gm/kg/26W-C
TOXIC EFFECTS :
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 27,493,1977
 
                            *** END OF RECORD ***