*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : XI6550000
CHEMICAL NAME           : Thiamine, chloride
CAS REGISTRY NUMBER     : 59-43-8
LAST UPDATED            : 199701
DATA ITEMS CITED        : 8
MOLECULAR FORMULA       : C12-H17-N4-O-S.Cl
MOLECULAR WEIGHT        : 300.84
WISWESSER LINE NOTATION : T6N CNJ B1 DZ E1- AT5K CSJ D2Q E1 &Q &G
COMPOUND DESCRIPTOR     : Drug
                          Reproductive Effector
                          Human
SYNONYMS/TRADE NAMES :
   * B-Amin
   *   3-((4-Amino-2-methyl-5-pyrimidinyl)methyl)-5-(2-hydroxyethyl)-4-methylth
     iazolium chloride
   * Aneurine
   * Apatate drape
   * Beivon
   * Betabion
   * Bethiamin
   * Oryzanin
   * Oryzanine
   * Thiamin
   * Thiamine
   * Thiamine monochloride
   * Vitamin B1
   * Vitaneurin
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Multiple routes
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 214 mg/kg/30W-I
TOXIC EFFECTS :
   Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
   ZYZAEU Zhongguo Yaoxue Zazhi. Chinese Pharmacuetical Journal. (China
   International Book Trading Corp., POB 2820, Beijing, Peop. China) V.24-
   1989-  Volume(issue)/page/year: 30,407,1995
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 301 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 119,444,1957
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 20 mg/kg
SEX/DURATION            : female 8 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - Central Nervous System
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   TOIZAG Toho Igakkai Zasshi.  Journal of Medical Society of Toho University.
   (Toho Daigaku Igakkai, 21-16, Omori-nishi, 5-chome, Ota-ku, Tokyo 143,
   Japan)  V.1-    1954-  Volume(issue)/page/year: 8,175,1961

                              *** REVIEWS ***
 
   TOXICOLOGY REVIEW
   IRXPAT International Review of Experimental Pathology.  (Academic Press,
   Inc., 1 E. First St., Duluth, MN 55802)  V.1-    1962-
   Volume(issue)/page/year: 3,219,1964

   TOXICOLOGY REVIEW
   CRTXB2 CRC Critical Reviews in Toxicology.  (CRC Press, Inc., 2000 Corporate
   Blvd., NW, Boca Raton, FL 33431)  V.1-    1971- Volume(issue)/page/year:
   2,365,1973

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - 82022
       No. of Facilities: 1673 (estimated)
       No. of Industries: 7
       No. of Occupations: 9
       No. of Employees: 5002 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - 82022
       No. of Facilities: 813 (estimated)
       No. of Industries: 6
       No. of Occupations: 20
       No. of Employees: 18939 (estimated)
       No. of Female Employees: 9502 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY

 
                            *** END OF RECORD ***