*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : XJ5952000
CHEMICAL NAME           : 5-Thiazolidineethanol,
                          3-((4-amino-2-methyl-5-pyrimidinyl)methyl)-4-methyl-
CAS REGISTRY NUMBER     : 15233-41-7
LAST UPDATED            : 199706
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C12-H20-N4-O-S
MOLECULAR WEIGHT        : 268.42
SYNONYMS/TRADE NAMES :
   * 3-((4-Amino-2-methyl-5-pyrimidinyl)methyl)-4-methyl-5-thiazolidineethanol
   * Tetrahydrothiamin
   * Tetrahydrothiamine
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 430 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   VABBA3 Vestsi Akademii Navuk Belaruskai SSR, Seryya Biyalagichnykh Navuk.
   Proceedings of the Academy of Sciences of the Belorussian SSR, Biological
   Sciences Series.  (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  No. 1-
   1956-  Volume(issue)/page/year: (6),54,1977
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1150 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   VABBA3 Vestsi Akademii Navuk Belaruskai SSR, Seryya Biyalagichnykh Navuk.
   Proceedings of the Academy of Sciences of the Belorussian SSR, Biological
   Sciences Series.  (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  No. 1-
   1956-  Volume(issue)/page/year: (6),54,1977
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1200 mg/kg/30D-I
TOXIC EFFECTS :
   Brain and Coverings - other degenerative changes
   Blood - changes in spleen
   Biochemical - Enzyme inhibition, induction, or change in blood or tissue
   levels - other Enzymes
REFERENCE :
   VABBA3 Vestsi Akademii Navuk Belaruskai SSR, Seryya Biyalagichnykh Navuk.
   Proceedings of the Academy of Sciences of the Belorussian SSR, Biological
   Sciences Series.  (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  No. 1-
   1956-  Volume(issue)/page/year: (6),54,1977
 
                            *** END OF RECORD ***