*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : XJ7050290 CHEMICAL NAME : Thiazolium, 5-(2-hydroxyethyl)-3-((4-hydroxy-2-methyl-5-pyrimidin yl)methyl)-4-methyl- CAS REGISTRY NUMBER : 136-16-3 BEILSTEIN REFERENCE NO. : 4153910 LAST UPDATED : 199612 DATA ITEMS CITED : 2 MOLECULAR FORMULA : C12-H16-N3-O2-S MOLECULAR WEIGHT : 266.37 WISWESSER LINE NOTATION : T6N CNJ B1 DQ E1- AT5N CSJ D2Q E1 COMPOUND DESCRIPTOR : Drug Reproductive Effector SYNONYMS/TRADE NAMES : * 5-(2-Hydroxyethyl)-3-((4-hydroxy-2-methyl-5-pyrimidinyl)methyl)-4-methyl -thiazolium * Oxythiamin * Oxythiamine *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1430 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 16,848,1982 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE : 160 mg/kg SEX/DURATION : female 1-8 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) REFERENCE : FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave. S, Birmingham, AL 35282) V.1- 1950- Volume(issue)/page/year: 24,962,1973 *** END OF RECORD ***