*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : XJ7050290
CHEMICAL NAME           : Thiazolium,
                          5-(2-hydroxyethyl)-3-((4-hydroxy-2-methyl-5-pyrimidin
                          yl)methyl)-4-methyl-
CAS REGISTRY NUMBER     : 136-16-3
BEILSTEIN REFERENCE NO. : 4153910
LAST UPDATED            : 199612
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C12-H16-N3-O2-S
MOLECULAR WEIGHT        : 266.37
WISWESSER LINE NOTATION : T6N CNJ B1 DQ E1- AT5N CSJ D2Q E1
COMPOUND DESCRIPTOR     : Drug
                          Reproductive Effector
SYNONYMS/TRADE NAMES :
   *   5-(2-Hydroxyethyl)-3-((4-hydroxy-2-methyl-5-pyrimidinyl)methyl)-4-methyl
     -thiazolium
   * Oxythiamin
   * Oxythiamine
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1430 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PCJOAU Pharmaceutical Chemistry Journal (English Translation).  Translation
   of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013)  No.1-
   1967-  Volume(issue)/page/year: 16,848,1982
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 160 mg/kg
SEX/DURATION            : female 1-8 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
   number of implants per female; total number of implants per corpora lutea)
REFERENCE :
   FESTAS Fertility and Sterility.  (American Fertility Soc., 608 13th Ave. S,
   Birmingham, AL 35282) V.1-    1950-  Volume(issue)/page/year: 24,962,1973
 
                            *** END OF RECORD ***