*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : XJ7055400
CHEMICAL NAME           : 5H-Thiazolo(3,2-a)pyrimidin-7-ol,
                          6,7-dihydro-3,5,5,7-tetramethyl-, monohydrochloride
CAS REGISTRY NUMBER     : 21457-22-7
LAST UPDATED            : 198406
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C10-H16-N2-O-S.Cl-H
MOLECULAR WEIGHT        : 248.80
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * 6,7-Dihydro-3,5,5,7-tetramethyl-5H-thiazolo(3,2-a)pyrimidin-7-ol  
   hydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 820 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - tremor
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   PHARAT Pharmazie.  (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18,
   Berlin DDR-1020, Ger. Dem. Rep.)  V.1-    1946-  Volume(issue)/page/year:
   24,572,1969
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 360 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - tremor
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   PHARAT Pharmazie.  (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18,
   Berlin DDR-1020, Ger. Dem. Rep.)  V.1-    1946-  Volume(issue)/page/year:
   24,572,1969
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 795 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PHARAT Pharmazie.  (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18,
   Berlin DDR-1020, Ger. Dem. Rep.)  V.1-    1946-  Volume(issue)/page/year:
   24,572,1969
 
                            *** END OF RECORD ***