*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : XJ9089200
CHEMICAL NAME           : Thieno(3,2-c)pyridine,
                          4,5,6,7-tetrahydro-5-((2-chlorophenyl)methyl)-
CAS REGISTRY NUMBER     : 55142-85-3
BEILSTEIN REFERENCE NO. : 1216802
LAST UPDATED            : 199712
DATA ITEMS CITED        : 12
MOLECULAR FORMULA       : C14-H14-Cl-N-S
MOLECULAR WEIGHT        : 263.80
COMPOUND DESCRIPTOR     : Drug
                          Human
SYNONYMS/TRADE NAMES :
   * 5-((2-Chlorophenyl)methyl)-4,5,6,7-tetrahydrothieno(3,2-c)pyridine
   * PCR 5332
   * Ticlopidine
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 336 mg/kg/47D-I
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - other changes
   Blood - agranulocytosis
   Blood - thrombocytopenia
REFERENCE :
   APHRER Annals of Pharmacotherpy.  (Harvey Whitney Books Co., POB 42696,
   Cincinnati, OH 45242) V. 26-    1992-  Volume(issue)/page/year: 28,1236,1994
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 600 mg/kg/60D-I
TOXIC EFFECTS :
   Blood - aplastic anemia
   Blood - changes in bone marrow (not otherwise specified)
   Nutritional and Gross Metabolic - body temperature increase
REFERENCE :
   IJMDAI Israel Journal of Medical Sciences.  (POB 1435, Jerusalem 91013,
   Israel)  V.1-    1965-  Volume(issue)/page/year: 31,444,1995
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 429 mg/kg/6OD-I
TOXIC EFFECTS :
   Gastrointestinal - hypermotility, diarrhea
REFERENCE :
   LANCAO Lancet.  (7 Adam St., London WC2N 6AD, UK)  V.1-    1823-
   Volume(issue)/page/year: 1,407,1984
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 100 mg/kg/10D-I
TOXIC EFFECTS :
   Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
   acute tubular necrosis)
   Kidney, Ureter, Bladder - urine volume decreased
   Blood - eosinophilia
REFERENCE :
   AJKDDP American Journal of Kidney Diseases.  (Grune & Stratton, Inc.,
   Journal Subscription Dept., POB 6280, Duluth, MN 55806)  V.1-    1981-
   Volume(issue)/page/year: 25,934,1995
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1780 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - pleural thickening
   Skin and Appendages - hair
REFERENCE :
   NDADD8 New Drugs Annual: Cardiovascular Drugs.  (New York, NY)  V.1-2,
   1983-84.  For publisher information, see NCDREP.  Volume(issue)/page/year:
   1,295,1983
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >5 gm/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - pleural thickening
   Skin and Appendages - hair
REFERENCE :
   NDADD8 New Drugs Annual: Cardiovascular Drugs.  (New York, NY)  V.1-2,
   1983-84.  For publisher information, see NCDREP.  Volume(issue)/page/year:
   1,295,1983
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 70 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - pleural thickening
   Skin and Appendages - hair
REFERENCE :
   NDADD8 New Drugs Annual: Cardiovascular Drugs.  (New York, NY)  V.1-2,
   1983-84.  For publisher information, see NCDREP.  Volume(issue)/page/year:
   1,295,1983
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 600 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - pleural thickening
   Skin and Appendages - hair
REFERENCE :
   NDADD8 New Drugs Annual: Cardiovascular Drugs.  (New York, NY)  V.1-2,
   1983-84.  For publisher information, see NCDREP.  Volume(issue)/page/year:
   1,295,1983
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1250 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - pleural thickening
   Skin and Appendages - hair
REFERENCE :
   NDADD8 New Drugs Annual: Cardiovascular Drugs.  (New York, NY)  V.1-2,
   1983-84.  For publisher information, see NCDREP.  Volume(issue)/page/year:
   1,295,1983
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 88 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - pleural thickening
   Skin and Appendages - hair
REFERENCE :
   NDADD8 New Drugs Annual: Cardiovascular Drugs.  (New York, NY)  V.1-2,
   1983-84.  For publisher information, see NCDREP.  Volume(issue)/page/year:
   1,295,1983
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Primate - monkey
DOSE/DURATION           : >6 gm/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - pleural thickening
   Skin and Appendages - hair
REFERENCE :
   NDADD8 New Drugs Annual: Cardiovascular Drugs.  (New York, NY)  V.1-2,
   1983-84.  For publisher information, see NCDREP.  Volume(issue)/page/year:
   1,295,1983
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Primate - monkey
DOSE/DURATION           : 500 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - pleural thickening
   Skin and Appendages - hair
REFERENCE :
   NDADD8 New Drugs Annual: Cardiovascular Drugs.  (New York, NY)  V.1-2,
   1983-84.  For publisher information, see NCDREP.  Volume(issue)/page/year:
   1,295,1983
 
                            *** END OF RECORD ***