*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : XP2074000
CHEMICAL NAME           : Thymidine,
                          2'-deoxy-P-thiocytidylyl-(5'-3')-P-thiothymidylyl(5'-
                          3')-2'-deoxy-P-thiogu anylyl-
                          (5'-3')-2'-deoxy-P-thiocytidylyl-(5'-3')-P-thiothymid
                          ylyl-(5'-3')-2'-deoxy -P-thiocytidylyl-
                          (5'-3')-2'-deoxy-P-thiocytidylyl-(5'-3')-P-thiothymid
                          ylyl-(5'-3')-P-thioth ymidylyl-(5'-3)-2'-
                          deoxy-P-thiocytidylyl-(5'-3')-P-thiothymidylyl-(5'-3'
                          )-2'-deoxy-P-thioaden ylyl-(5'-3')-2'-
                          deoxy-P-thiocytidylyl-(5'-3')-2'-deoxy-P-thiocytidyly
                          l-(5'-3')-P-thiothymi dylyl-(5'-3')-P-
                          thiothymidylyl-(5'-3')-2'-deoxy-P-thiocytidylyl-(5'-3
                          ')-2'-deoxy-P-thiogua nylyl-(5'-3')-P-
                          thiothymidylyl-(5'-3')-, nonadecasodium salt
CAS REGISTRY NUMBER     : 138330-98-0
LAST UPDATED            : 199806
DATA ITEMS CITED        : 1
MOLECULAR FORMULA       : C192-H250-N57-O107-P19-S19.19Na
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Afovirsen sodium
   * I 2105
   * IP 2105
   * ISIS 2105
 
                       *** HEALTH HAZARD DATA ***
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intradermal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 304 mg/kg/14D-I
TOXIC EFFECTS :
   Endocrine - changes in spleen weight
   Blood - changes in erythrocyte (RBC) count
   Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
   TXCYAC Toxicology.  (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
   Limerick, Ireland) V.1-    1973-  Volume(issue)/page/year: 116,77,1997
 
                            *** END OF RECORD ***