*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : XP2087500
CHEMICAL NAME : Thymidine, alpha,alpha,alpha-trifluoro-
CAS REGISTRY NUMBER : 70-00-8
BEILSTEIN REFERENCE NO. : 0568095
LAST UPDATED : 199612
DATA ITEMS CITED : 16
MOLECULAR FORMULA : C10-H11-F3-N2-O5
MOLECULAR WEIGHT : 296.23
WISWESSER LINE NOTATION : T6NVMVJ EXFFF A- ET5OTJ B1Q CQ
COMPOUND DESCRIPTOR : Mutagen
SYNONYMS/TRADE NAMES :
* 2'-Deoxy-5-(trifluoromethyl)uridine
* F3DThd
* F3T
* F3TDR
* NSC 75520
* 2,4(1H,3H)-Pyrimidinedione,
1-(2-deoxy-beta-D-ribofuranosyl)-5-(trifluoromethyl)-
* TFDU
* 5-Trifluoro-2'-deoxythymidine
* Trifluoromethyldeoxyuridine
* 5-(Trifluoromethyl)deoxyuridine
* 5-Trifluoromethyl-2-deoxyuridine
* 5-(Trifluoromethyl)-2'-deoxyuridine
* Trifluorothymidine
* alpha,alpha,alpha-Trifluorothymidine
* Trifluridine
* Uridine, 2'-deoxy-5-(trifluoromethyl)-
* Viroptic
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 2946 mg/kg
TOXIC EFFECTS :
Liver - other changes
REFERENCE :
NCIAL* Progress Report Submitted to the National Cancer Institute by Arthur
D. Little, Inc. (15 Acorn Park, Cambridge, MA 02140)
Volume(issue)/page/year: -,260,1967
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1931 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NCISP* National Cancer Institute Screening Program Data Summary,
Developmental Therapeutics Program. (Bethesda, MD 20205)
Volume(issue)/page/year: JAN1986
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 3381 mg/kg
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
NCIAL* Progress Report Submitted to the National Cancer Institute by Arthur
D. Little, Inc. (15 Acorn Park, Cambridge, MA 02140)
Volume(issue)/page/year: -,260,1967
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Primate - monkey
DOSE/DURATION : 400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GVRAAS Government Reports Announcements. (U.S.) (Washington, D.C.) V.71(6)
-75(6), 1971-75. Merged with Government Reports Index (US) to form
Government Reports Announcement Index (U.S.) Volume(issue)/page/year:
74(9),60,1974
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 187 mg/kg/15D-I
TOXIC EFFECTS :
Gastrointestinal - changes in structure or function of salivary glands
Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
acute tubular necrosis)
Blood - leukopenia
REFERENCE :
NCIAL* Progress Report Submitted to the National Cancer Institute by Arthur
D. Little, Inc. (15 Acorn Park, Cambridge, MA 02140)
Volume(issue)/page/year: -,260,1967
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Primate - monkey
DOSE/DURATION : 2600 mg/kg/90D-I
TOXIC EFFECTS :
Liver - other changes
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - transaminases
REFERENCE :
GVRAAS Government Reports Announcements. (U.S.) (Washington, D.C.) V.71(6)
-75(6), 1971-75. Merged with Government Reports Index (US) to form
Government Reports Announcement Index (U.S.) Volume(issue)/page/year:
74(9),60,1974
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Primate - monkey
DOSE/DURATION : 2100 mg/kg/14D-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - chronic pulmonary edema
Gastrointestinal - hypermotility, diarrhea
Related to Chronic Data - death
REFERENCE :
NCIAL* Progress Report Submitted to the National Cancer Institute by Arthur
D. Little, Inc. (15 Acorn Park, Cambridge, MA 02140)
Volume(issue)/page/year: -,260,1967
** MUTATION DATA **
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 500 ug/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 169,123,1986
TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Human Lymphocyte
DOSE/DURATION : 500 ug/L
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540,
08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year:
7,520,1982
TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Human Lung
DOSE/DURATION : 500 ug/L
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540,
08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year:
7,520,1982
TYPE OF TEST : Mutation in mammalian somatic cells
TEST SYSTEM : Rodent - mouse Lymphocyte
DOSE/DURATION : 150 ug/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 312,85,1994
TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Rodent - hamster Ovary
DOSE/DURATION : 16 mg/L
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
86,180,1986
TYPE OF TEST : Mutation in mammalian somatic cells
TEST SYSTEM : Rodent - hamster Lung
DOSE/DURATION : 1 mg/L
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
Volume(issue)/page/year: 6,1207,1985
TYPE OF TEST : Mutation in mammalian somatic cells
TEST SYSTEM : Rodent - hamster Ovary
DOSE/DURATION : 4 mg/L
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
86,180,1986
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X3218
No. of Facilities: 3 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 82 (estimated)
No. of Female Employees: 14 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Negative: Cell transform.-C3H/10T1/2; V79 cell
culture-gene mutation
*** END OF RECORD ***