*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : XP3582400 CHEMICAL NAME : Thyroxine CAS REGISTRY NUMBER : 7488-70-2 LAST UPDATED : 199504 DATA ITEMS CITED : 10 MOLECULAR FORMULA : C15-H11-I4-N-O4 MOLECULAR WEIGHT : 776.87 WISWESSER LINE NOTATION : QVYZ1R CI EI DOR DQ CI EI COMPOUND DESCRIPTOR : Mutagen Reproductive Effector Human SYNONYMS/TRADE NAMES : * 3-(4-(4-Hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl)alanine * O-(4-Hydroxy-3,5-diiodophenyl)-3,5-diiodotyrosine * Tyrosine, O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo- *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - man DOSE/DURATION : 30 ug/kg/3W-I TOXIC EFFECTS : Cardiac - EKG changes not diagnostic of specified effects REFERENCE : BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year: 292,1185,1986 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - woman DOSE/DURATION : 42 ug/kg/1W-I TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold REFERENCE : NEURAI Neurology. (Modern Medicine Pub., Inc., 1 E. First St., Duluth, MN 55802) V.1- 1951- Volume(issue)/page/year: 35,1792,1985 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE : 30 mg/kg SEX/DURATION : female 9-20 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - abortion Reproductive - Specific Developmental Abnormalities - eye/ear REFERENCE : AFPEAM Archives Francaises de Pediatrie. (Doin Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1942- Volume(issue)/page/year: 11,168,1954 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE : 27500 ug/kg SEX/DURATION : female 1-22 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - eye/ear REFERENCE : BSOFAK Bulletin des Societes d'Ophthalmologie de France. (Diffusion Litteraire et Scientifique, 3 rue Fortia, 13001 Marseilles, France) 1949- Volume(issue)/page/year: (5),543,1951 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Rodent - rat DOSE : 19310 ug/kg SEX/DURATION : female 7 day(s) pre-mating TOXIC EFFECTS : Reproductive - Maternal Effects - ovaries, fallopian tubes REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 99,97,1954 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE : 5 mg/kg SEX/DURATION : female 10-13 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 84,115,1986 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Rodent - rabbit DOSE : 500 ug/kg SEX/DURATION : female 25-26 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - other effects to embryo REFERENCE : DPTHDL Developmental Pharmacology and Therapeutics. (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.1- 1980- Volume(issue)/page/year: 9,115,1986 ** MUTATION DATA ** TYPE OF TEST : Unscheduled DNA synthesis ROUTE OF EXPOSURE : Subcutaneous TEST SYSTEM : Rodent - rat DOSE/DURATION : 3125 ug/kg REFERENCE : BEXBAN Bulletin of Experimental Biology and Medicine (English Translation). Translation of BEBMAE. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.41- 1956- Volume(issue)/page/year: 72,942,1971 TYPE OF TEST : Cytogenetic analysis ROUTE OF EXPOSURE : Intraperitoneal TEST SYSTEM : Rodent - mouse DOSE/DURATION : 250 ug/kg/7D REFERENCE : RRENAR Revue Roumaine d'Endocrinologie. (Bucharest, Romania) V.1-11, 1964-74. For publisher information, see RRENDU. Volume(issue)/page/year: 10,149,1973 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X2294 No. of Facilities: 19 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 225 (estimated) No. of Female Employees: 225 (estimated) *** END OF RECORD ***