*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : XR1700000
CHEMICAL NAME           : Titanium
CAS REGISTRY NUMBER     : 7440-32-6
LAST UPDATED            : 199710
DATA ITEMS CITED        : 12
MOLECULAR FORMULA       : Ti
MOLECULAR WEIGHT        : 47.90
WISWESSER LINE NOTATION : .TI
COMPOUND DESCRIPTOR     : Tumorigen
                          Reproductive Effector
SYNONYMS/TRADE NAMES :
   * Contimet 30
   * C.P. titanium
   * IMI 115
   * NCI-C04251
   * Oremet
   * T 40
   * Titanate
   * Titanium 50A
   * Titanium alloy
   * VT 1
 
                       *** HEALTH HAZARD DATA ***
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 114 mg/kg/77W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Blood - lymphoma, including Hodgkin's disease
   Tumorigenic - tumors at site of application
REFERENCE :
   NCIUS* Progress Report for Contract No. PH-43-64-886, Submitted to the
   National Cancer Institute by The Institute of Chemical Biology, University
   of San Francisco.  (San Francisco, CA 94117)  Volume(issue)/page/year:
   PH43-64-886
 
TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 360 mg/kg/69W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Blood - lymphoma, including Hodgkin's disease
   Tumorigenic - tumors at site of application
REFERENCE :
   NCIUS* Progress Report for Contract No. PH-43-64-886, Submitted to the
   National Cancer Institute by The Institute of Chemical Biology, University
   of San Francisco.  (San Francisco, CA 94117)  Volume(issue)/page/year:
   PH43-64-886
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 158 mg/kg
SEX/DURATION            : multigeneration
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
   AEHLAU Archives of Environmental Health.  (Heldref Pub., 4000 Albemarle St.,
   NW, Washington, DC 20016)  V.1-    1960-  Volume(issue)/page/year:
   23,102,1971

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - 73255
       No. of Facilities: 1060 (estimated)
       No. of Industries: 36
       No. of Occupations: 42
       No. of Employees: 21978 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - X5095
       No. of Facilities: 9 (estimated)
       No. of Industries: 2
       No. of Occupations: 5
       No. of Employees: 250 (estimated)
       No. of Female Employees: 53 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - X5916
       No. of Facilities: 6 (estimated)
       No. of Industries: 2
       No. of Occupations: 2
       No. of Employees: 1198 (estimated)
       No. of Female Employees: 400 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - 73255
       No. of Facilities: 11591 (estimated)
       No. of Industries: 113
       No. of Occupations: 97
       No. of Employees: 189763 (estimated)
       No. of Female Employees: 9744 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY
   
   EPA TSCA Section 8(d) unpublished health/safety studies
   
   EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
   
   NIOSH Analytical Method, 1994: Elements by ICP, 7300
   
   NIOSH Analytical Method, 1994: Metals in urine, 8310

 
                            *** END OF RECORD ***