*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : XR2275000
CHEMICAL NAME           : Titanium oxide
CAS REGISTRY NUMBER     : 13463-67-7
OTHER CAS REGISTRY NOS. : 1309-63-3
LAST UPDATED            : 199712
DATA ITEMS CITED        : 41
MOLECULAR FORMULA       : O2-Ti
MOLECULAR WEIGHT        : 79.90
WISWESSER LINE NOTATION : TI  O2
COMPOUND DESCRIPTOR     : Tumorigen
                          Mutagen
                          Primary Irritant
SYNONYMS/TRADE NAMES :
   * A-Fil Cream
   * Atlas white titanium dioxide
   * Austiox R-CR 3
   * Bayertitan
   * Baytitan
   * Brookite
   * Calcotone White T
   * C.I. 77891
   * C.I. Pigment White 6
   * Cosmetic White C47-5175
   * Cosmetic White C47-9623
   * C-Weiss 7
   * E 171
   * Flamenco
   * Hombitan
   * Horse Head A-410
   * Horse Head A-420
   * Horse Head R-710
   * KH 360
   * Kronos
   * Kronos titanium dioxide
   * Levanox White RKB
   * NCI-C04240
   * Pigment White 6
   * Rayox
   * Runa RH20
   * Rutiox CR
   * Tichlor
   * Tiofine
   * Tiona T.D.
   * Tioxide
   * Tipaque
   * Ti-Pure
   * Titafrance
   * Titandioxid
   * Titanium dioxide
   * Titanium peroxide
   * Titanox
   * Titanox 2010
   * Titan White
   * Trioxide(S)
   * Tronox
   * Unitane
   * Unitane O-110
   * Unitane O-220
   * Unitane OR-150
   * Unitane OR-340
   * Unitane OR-342
   * Unitane OR-350
   * Unitane OR-540
   * Unitane OR-640
   * 1700 White
   * Zopaque
 
                       *** HEALTH HAZARD DATA ***
 
                      ** SKIN/EYE IRRITATION DATA **
 
TYPE OF TEST            : Standard Draize test
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Human
DOSE/DURATION           : 300 ug/3D (Intermittent)
REACTION SEVERITY       : Mild
REFERENCE :
   85DKA8 "Cutaneous Toxicity, Proceedings of the 3rd Conference, 1976," Drill,
   V.A., and P. Lazar, eds., New York, Academic Press, Inc. 1977
   Volume(issue)/page/year: -,127,1977
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 250 mg/m3/6H/4W-I
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - chronic pulmonary edema
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   145,10,1997
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 250 mg/m3/6H/2Y-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   79,179,1985
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 360 mg/kg/2Y-I
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Blood - lymphoma, including Hodgkin's disease
   Tumorigenic - tumors at site of application
REFERENCE :
   NCIUS* Progress Report for Contract No. PH-43-64-886, Submitted to the
   National Cancer Institute by The Institute of Chemical Biology, University
   of San Francisco.  (San Francisco, CA 94117)  Volume(issue)/page/year:
   PH43-64-886
 
TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 260 mg/kg/84W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Blood - lymphoma, including Hodgkin's disease
   Tumorigenic - tumors at site of application
REFERENCE :
   NCIUS* Progress Report for Contract No. PH-43-64-886, Submitted to the
   National Cancer Institute by The Institute of Chemical Biology, University
   of San Francisco.  (San Francisco, CA 94117)  Volume(issue)/page/year:
   PH43-64-886
 
TYPE OF TEST            : TC - Toxic concentration (other than lowest)
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 10 mg/m3/18H/2Y-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
REFERENCE :
   INHTE5 Inhalation Toxicology.  (Hemisphere Publishing Corp., c/o Taylor &
   Francis Inc., 1900 Frost Rd., Suite 101, Bristol, PA 19007)  V.1-    1989-
   Volume(issue)/page/year: 7,533,1995
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Micronucleus test
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 3 gm/kg/3D (Continuous)
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   21,160,1993
 
TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 500 mg/L
REFERENCE :
   TIVIEQ Toxicology In Vitro.  (Pergamon Press Inc., Maxwell House, Fairview
   Park, Elmsford, NY 10523) V.1-   1987-  Volume(issue)/page/year: 1,71,1987

                              *** REVIEWS ***
 
   ACGIH TLV-Not classifiable as a human carcinogen
   DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
   (BEIs) booklet issues by American Conference of Governmental Industrial
   Hygienists (ACGIH), Cincinnati, OH, 1996  Volume(issue)/page/year:
   TLV/BEI,1997

   ACGIH TLV-TWA 10 mg/m3
   DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
   (BEIs) booklet issues by American Conference of Governmental Industrial
   Hygienists (ACGIH), Cincinnati, OH, 1996  Volume(issue)/page/year:
   TLV/BEI,1997

   IARC Cancer Review:Animal Limited Evidence
   IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
   to Man.  (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
   V.1-    1972-  Volume(issue)/page/year: 47,307,1989

   IARC Cancer Review:Human Inadequate Evidence
   IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
   to Man.  (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
   V.1-    1972-  Volume(issue)/page/year: 47,307,1989

   IARC Cancer Review:Group 3
   IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
   to Man.  (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
   V.1-    1972-  Volume(issue)/page/year: 47,307,1989

                    *** U.S. STANDARDS AND REGULATIONS ***
 
   MSHA STANDARD:NUISANCE PARTICULATES
   DTLWS* "Documentation of the Threshold Limit Values for Substances in
   Workroom Air," Supplements. For publisher information, see 85INA8.
   Volume(issue)/page/year: 3,29,1973

   OSHA PEL (Gen Indu):8H TWA 15 mg/m3, total dust
   CFRGBR Code of Federal Regulations.  (U.S. Government Printing Office, Supt.
   of Documents, Washington, DC 20402)  Volume(issue)/page/year:
   29,1910.1000,1994

   OSHA PEL (Gen Indu):8H TWA 5 mg/m3, respirable fraction
   CFRGBR Code of Federal Regulations.  (U.S. Government Printing Office, Supt.
   of Documents, Washington, DC 20402)  Volume(issue)/page/year:
   29,1910.1000,1994

   OSHA PEL (Construc):8H TWA 15 mg/m3, total dust
   CFRGBR Code of Federal Regulations.  (U.S. Government Printing Office, Supt.
   of Documents, Washington, DC 20402)  Volume(issue)/page/year:
   29,1926.55,1994

   OSHA PEL (Shipyard):8H TWA 15 mg/m3, total dust
   CFRGBR Code of Federal Regulations.  (U.S. Government Printing Office, Supt.
   of Documents, Washington, DC 20402)  Volume(issue)/page/year:
   29,1915.1000,1993

   OSHA PEL (Fed Cont):8H TWA 15 mg/m3
   CFRGBR Code of Federal Regulations.  (U.S. Government Printing Office, Supt.
   of Documents, Washington, DC 20402)  Volume(issue)/page/year:
   41,50-204.50,1994

                    *** OCCUPATIONAL EXPOSURE LIMITS ***
 
   OEL-ARAB Republic of Egypt:TWA 15 mg/m3 JAN 1993
   
   OEL-AUSTRALIA:TWA 10 mg/m3 JAN 1993
   
   OEL-BELGIUM:TWA 10 mg/m3 JAN 1993
   
   OEL-DENMARK:TWA 6 mg/m3 JAN 1993
   
   OEL-FRANCE:TWA 10 mg/m3 JAN 1993
   
   OEL-GERMANY:TWA 6 mg/m3 JAN 1993
   
   OEL-THE PHILIPPINES:TWA 15 mg/m3 JAN 1993
   
   OEL-SWITZERLAND:TWA 6 mg/m3 JAN 1993
   
   OEL-TURKEY:TWA 15 mg/m3 JAN 1993
   
   OEL-UNITED KINGDOM:TWA 10 mg/m3 (total dust) JAN 1993
   
   OEL-UNITED KINGDOM:TWA 5 mg/m3 (resp. dust) JAN 1993
   
   OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
   
   OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
   NIOSH REL TO TITANIUM DIOXIDE-air:CA lowest feasible concentration
REFERENCE :
   NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of
   Health, Education, and Welfare, Reports and Memoranda.
   Volume(issue)/page/year: DHHS #92-100,1992

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - M0913
       No. of Facilities: 8751 (estimated)
       No. of Industries: 112
       No. of Occupations: 78
       No. of Employees: 117618 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - M0913
       No. of Facilities: 167223 (estimated)
       No. of Industries: 425
       No. of Occupations: 246
       No. of Employees: 2749569 (estimated)
       No. of Female Employees: 540849 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Negative: Carcinogenicity-mouse/rat; Cell
   transform.-SA7/SHE
   
   EPA TSCA Section 8(b) CHEMICAL INVENTORY
   
   EPA TSCA Section 8(d) unpublished health/safety studies
   
   EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
   
   NIOSH Analytical Method, 1994: Elements by ICP, 7300
   
   NCI Carcinogenesis Bioassay (feed);no evidence:mouse,rat
   NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
   (Bethesda, MD)  No.0-205. For publisher information, see NTPTR*.
   Volume(issue)/page/year: NCI-TR-97,79

 
                            *** END OF RECORD ***