*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : XS5250000
CHEMICAL NAME : Toluene
CAS REGISTRY NUMBER : 108-88-3
LAST UPDATED : 199801
DATA ITEMS CITED : 127
MOLECULAR FORMULA : C7-H8
MOLECULAR WEIGHT : 92.15
WISWESSER LINE NOTATION : 1R
COMPOUND DESCRIPTOR : Tumorigen
Mutagen
Reproductive Effector
Human
Primary Irritant
SYNONYMS/TRADE NAMES :
* Antisal 1a
* Benzene, methyl-
* CP 25
* Methacide
* Methane, phenyl-
* Methylbenzene
* Methylbenzol
* NCI-C07272
* Phenylmethane
* RCRA waste number U220
* Tolueen
* Toluen
* Toluene
* Tolueno
* Toluol
* Toluolo
* Tolu-Sol
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration into the eye
SPECIES OBSERVED : Human
DOSE/DURATION : 300 ppm
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 25,282,1943
TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 435 mg
REACTION SEVERITY : Mild
REFERENCE :
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury
Rd., Danbury, CT 06817) Volume(issue)/page/year: 7/23/1970
TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 500 mg
REACTION SEVERITY : Moderate
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year:
20,563,1982
TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 20 mg/24H
REACTION SEVERITY : Moderate
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,29,1986
TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration into the eye
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 870 ug
REACTION SEVERITY : Mild
REFERENCE :
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury
Rd., Danbury, CT 06817) Volume(issue)/page/year: 7/23/1970
TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration into the eye
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 2 mg/24H
REACTION SEVERITY : Severe
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,29,1986
TYPE OF TEST : Rinsed with water
ROUTE OF EXPOSURE : Administration into the eye
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 100 mg/30S
REACTION SEVERITY : Mild
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year:
20,573,1982
** ACUTE TOXICITY DATA **
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human
DOSE/DURATION : 50 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka
Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959-
Volume(issue)/page/year: 22,883,1980
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Human
DOSE/DURATION : 200 ppm
TOXIC EFFECTS :
Brain and Coverings - recordings from specific areas of CNS
Behavioral - antipsychotic
Blood - changes in bone marrow (not otherwise specified)
REFERENCE :
JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N.
Dearborn St., Chicago, IL 60610) V.1- 1883- Volume(issue)/page/year:
123,1106,1943
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Human - man
DOSE/DURATION : 100 ppm
TOXIC EFFECTS :
Behavioral - hallucinations, distorted perceptions
Behavioral - changes in motor activity (specific assay)
Behavioral - changes in psychophysiological tests
REFERENCE :
WEHRBJ Work, Environment, Health. (Helsinki, Finland) V.1-11, 1962-74. For
publisher information, see SWEHDO. Volume(issue)/page/year: 9,131,1972
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 636 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NRTXDN Neurotoxicology. (Intox Press, Inc., POB 34075, Little Rock, AR
72203) V.1- 1979- Volume(issue)/page/year: 2,567,1981
TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 49 gm/m3/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 32(10),23,1988
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1332 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.1- 1967- Volume(issue)/page/year: 40,411,1986
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1960 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
MELAAD Medicina del Lavoro. Industrial Medicine. (Via S. Barnaba, 8, 20122
Milan, Italy) V.16- 1925- Volume(issue)/page/year: 54,486,1963
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 6900 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 45(12),64,1980
TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 400 ppm/24H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NRTXDN Neurotoxicology. (Intox Press, Inc., POB 34075, Little Rock, AR
72203) V.1- 1979- Volume(issue)/page/year: 2,567,1981
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 59 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NRTXDN Neurotoxicology. (Intox Press, Inc., POB 34075, Little Rock, AR
72203) V.1- 1979- Volume(issue)/page/year: 2,567,1981
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 2250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NRTXDN Neurotoxicology. (Intox Press, Inc., POB 34075, Little Rock, AR
72203) V.1- 1979- Volume(issue)/page/year: 8,237,1987
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 45(12),64,1980
TYPE OF TEST : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 55000 ppm/40M
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 26,69,1944
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 14100 uL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year:
30,470,1969
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 130 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HAEMAX Haematologica. (Il Pensiero Scientifico Editore, Via Panama 48,
I-00198, Rome, Italy) V.1- 1920- Volume(issue)/page/year: 58,491,1973
TYPE OF TEST : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 1600 ppm
TOXIC EFFECTS :
Behavioral - general anesthetic
Behavioral - somnolence (general depressed activity)
Behavioral - irritability
REFERENCE :
JIDHAN Journal of Industrial Hygiene. (Cambridge, MA) V.1-17, 1919-35. For
publisher information, see AEHLAU. Volume(issue)/page/year: 10,261,1928
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NRTXDN Neurotoxicology. (Intox Press, Inc., POB 34075, Little Rock, AR
72203) V.1- 1979- Volume(issue)/page/year: 2,567,1981
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Amphibian - frog
DOSE/DURATION : 920 mg/kg
TOXIC EFFECTS :
Autonomic Nervous System - other (direct) parasympathomimetic
Behavioral - convulsions or effect on seizure threshold
Behavioral - changes in motor activity (specific assay)
REFERENCE :
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher
information, see NSAPCC. Volume(issue)/page/year: 130,250,1928
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - species unspecified
DOSE/DURATION : 4 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 32(10),25,1988
TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Mammal - species unspecified
DOSE/DURATION : 30 gm/m3
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 32(10),25,1988
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Mammal - species unspecified
DOSE/DURATION : 1750 mg/kg
TOXIC EFFECTS :
Behavioral - muscle contraction or spasticity
Lungs, Thorax, or Respiration - other changes
REFERENCE :
AJHYA2 American Journal of Hygiene. (Baltimore, MD) V.1-80, 1921-64. For
publisher information, see AJEPAS. Volume(issue)/page/year: 7,276,1927
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 42380 mg/kg/49D-I
TOXIC EFFECTS :
Sense Organs and Special Senses (Ear) - changes in cochlear structure or
function
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.9- 1987- Volume(issue)/page/year:
10,525,1989
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 27645 mg/kg/3W-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - proteinuria
Kidney, Ureter, Bladder - other changes in urine composition
REFERENCE :
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway,
Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 5,62,1985
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 162 gm/kg/13W-I
TOXIC EFFECTS :
Brain and Coverings - changes in brain weight
Liver - changes in liver weight
Kidney, Ureter, Bladder - changes in bladder weight
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-371,1990
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1600 ppm/20H/7D-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - other changes
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Related to Chronic Data - death
REFERENCE :
AJHYA2 American Journal of Hygiene. (Baltimore, MD) V.1-80, 1921-64. For
publisher information, see AJEPAS. Volume(issue)/page/year: 7,276,1927
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 12000 ppm/10M/8W-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in bladder weight
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - transaminases
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
61,302,1981
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 300 ppm/6H/2Y-I
TOXIC EFFECTS :
Blood - pigmented or nucleated red blood cells
Blood - other changes
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year:
3,315,1983
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 2500 ppm/6.5H/15W-I
TOXIC EFFECTS :
Cardiac - changes in heart weight
Liver - changes in liver weight
Kidney, Ureter, Bladder - changes in bladder weight
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-371,1990
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1500 ppm/6H/26W-I
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes
Kidney, Ureter, Bladder - other changes
Biochemical - Neurotransmitters or modulators (putative) - dopamine in
striatum
REFERENCE :
PHTOEH Pharmacology and Toxicology (Copenhagen). (Munksgaard International
Pub., POB 2148, DK-1016 Copenhagen K, Denmark) V.60- 1987-
Volume(issue)/page/year: 68,384,1991
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 320 ppm/24H/30D-C
TOXIC EFFECTS :
Brain and Coverings - changes in brain weight
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Biochemical - Metabolism (Intermediary) - lipids including transport
REFERENCE :
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 45,123,1987
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 10500 mg/kg/7D-I
TOXIC EFFECTS :
Sense Organs and Special Senses (Ear) - changes in cochlear structure or
function
Behavioral - alteration of operant conditioning
REFERENCE :
NTOTDY Neurobehavioral Toxicology and Teratology. (Fayetteville, NY) V.3-8,
1981-86. For publisher information, see NETEEC. Volume(issue)/page/year:
8,103,1986
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 300 mg/m3/5H/21D-I
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise
specified
REFERENCE :
BCTKAG Bromatologia i Chemia Toksykologiczna. (Ars Polona, POB 1001, 00-068
Warsaw 1, Poland) V.4- 1971- Volume(issue)/page/year: 13,365,1980
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 2200 ppm/8H/23W-I
TOXIC EFFECTS :
Behavioral - ataxia
Musculoskeletal - other changes
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.9- 1987- Volume(issue)/page/year:
13,387,1991
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 11058 ug/kg/30D-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - other changes in urine composition
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - phosphatases
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - transaminases
REFERENCE :
TIHEEC Toxicology and Industrial Health. (Princeton Scientific Pub. Co.,
POB 2155, Princeton, NJ 08540) V.1- 1985- Volume(issue)/page/year:
9,479,1993
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 227 gm/kg/13W-I
TOXIC EFFECTS :
Brain and Coverings - changes in brain weight
Liver - changes in liver weight
Kidney, Ureter, Bladder - changes in bladder weight
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-371,1990
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 2940 mg/kg/4W-C
TOXIC EFFECTS :
Liver - changes in liver weight
Endocrine - changes in thymus weight
Immunological Including Allergic - decreased immune response
REFERENCE :
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.1- 1967- Volume(issue)/page/year: 49,93,1989
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 12000 ppm/10M/8W-I
TOXIC EFFECTS :
Liver - changes in liver weight
Kidney, Ureter, Bladder - changes in bladder weight
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
61,302,1981
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1250 ppm/6H/14W-I
TOXIC EFFECTS :
Liver - changes in liver weight
Related to Chronic Data - death
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-371,1990
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1000 ppm/6H/20D-I
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Blood - changes in erythrocyte (RBC) count
Blood - changes in leukocyte (WBC) count
REFERENCE :
JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological
Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku,
Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 2,363,1977
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 8400 mg/kg/14D-I
TOXIC EFFECTS :
Blood - changes in other cell count (unspecified)
Blood - changes in leukocyte (WBC) count
REFERENCE :
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New
York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 17,317,1994
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 50 mg/m3/4H/26W-I
TOXIC EFFECTS :
Behavioral - muscle contraction or spasticity
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 32(9),105,1967
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 7280 mg/kg
SEX/DURATION : female 6-19 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
PEREBL Pediatric Research. (Williams & Wilkins Co., 428 E. Preston St.,
Baltimore, MD 21202) V.1- 1967- Volume(issue)/page/year: 36,811,1994
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE : 1500 mg/m3/24H
SEX/DURATION : female 1-8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 11,55,1978
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE : 1000 mg/m3/24H
SEX/DURATION : female 7-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
FMORAO Folia Morphologica (Prague). (Plenum Pub. Corp. 233 Spring St., New
York, NY 10013) V.13- 1965- Volume(issue)/page/year: 28,286,1980
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE : 2000 ppm/6H
SEX/DURATION : female 7-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - other effects
Reproductive - Effects on Newborn - physical
REFERENCE :
JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological
Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku,
Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 20,109,1995
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE : 800 mg/m3/6H
SEX/DURATION : female 14-20 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Effects on Newborn - behavioral
REFERENCE :
BJMRDK Brazilian Journal of Medical and Biological Research. (Associacao
Brasileira de Divulgacao Cientifica, Faculdade de Medicina de Ribeirao
Preto, USP, 141000 Ribeirao Preto, SP, Brazil) V.14- 1981-
Volume(issue)/page/year: 23,533,1990
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE : 1200 ppm/6H
SEX/DURATION : female 9-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - delayed effects
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000
Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year:
71,258,1997
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE : 9 gm/kg
SEX/DURATION : female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development. (Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
Volume(issue)/page/year: 19,41A,1979
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE : 15 gm/kg
SEX/DURATION : female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development. (Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
Volume(issue)/page/year: 19,41A,1979
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE : 30 gm/kg
SEX/DURATION : female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development. (Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
Volume(issue)/page/year: 19,41A,1979
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - mouse
DOSE : 500 mg/m3/24H
SEX/DURATION : female 6-13 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 11,55,1978
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - mouse
DOSE : 1000 ppm/6H
SEX/DURATION : female 2-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
TJEMDR Tokai Journal of Experimental and Clinical Medicine. (Tokai Univ.
Press, Shinjuku Toka Bldg., 3-27-4 Shinjuku, Shinjuku-ku, Tokyo 160, Japan)
V.1- 1976- Volume(issue)/page/year: 7,265,1982
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - mouse
DOSE : 400 ppm/7H
SEX/DURATION : female 7-16 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
Reproductive - Effects on Newborn - biochemical and metabolic
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year:
6,145,1986
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - mouse
DOSE : 200 ppm/7H
SEX/DURATION : female 7-16 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year:
6,145,1986
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rabbit
DOSE : 1 gm/m3/24H
SEX/DURATION : female 7-20 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - abortion
REFERENCE :
ATSUDG Archives of Toxicology, Supplement. (Springer-Verlag New York, Inc.,
Service Center, 44 Hartz Way, Secaucus, NJ 07094) No.1- 1978-
Volume(issue)/page/year: 8,425,1985
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rabbit
DOSE : 100 ppm/6H
SEX/DURATION : female 6-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - cardiovascular
(circulatory) system
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000
Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year:
66,373,1992
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - hamster
DOSE : 800 mg/m3/6H
SEX/DURATION : female 6-11 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - behavioral
REFERENCE :
BJMRDK Brazilian Journal of Medical and Biological Research. (Associacao
Brasileira de Divulgacao Cientifica, Faculdade de Medicina de Ribeirao
Preto, USP, 141000 Ribeirao Preto, SP, Brazil) V.14- 1981-
Volume(issue)/page/year: 23,533,1990
** MUTATION DATA **
TYPE OF TEST : Unscheduled DNA synthesis
TEST SYSTEM : Bacteria - Escherichia coli
DOSE/DURATION : 1 pph
REFERENCE :
JOBAAY Journal of Bacteriology. (American Soc. for Microbiology, 1913 I
St., NW, Washington, DC 20006) V.1- 1916- Volume(issue)/page/year:
137,397,1979
TYPE OF TEST : Unscheduled DNA synthesis
TEST SYSTEM : Microorganism - not otherwise specified
DOSE/DURATION : 1 pph/15M (Continuous)
REFERENCE :
JOVIAM Journal of Virology. (American Soc. for Microbiology, 1913 I St.,
NW, Washington, DC 20006) V.1- 1967- Volume(issue)/page/year:
12,1195,1973
TYPE OF TEST : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Insect - Drosophila melanogaster
DOSE/DURATION : 1 pph
REFERENCE :
CONAEL Contaminacion Ambiental. (Centro de Ciencias de la Atmosfera,
Universidad Nacional Autonoma de Mexico, 04510 Mexico City, Mexico) V.1-
1985- Volume(issue)/page/year: 1,35,1985
TYPE OF TEST : Mutation test systems - not otherwise specified
ROUTE OF EXPOSURE : Inhalation
TEST SYSTEM : Insect - grasshopper
DOSE/DURATION : 20 pph/16H
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 113,467,1983
TYPE OF TEST : DNA damage
TEST SYSTEM : Rodent - rat Liver
DOSE/DURATION : 30 umol/L
REFERENCE :
SinJF# Personal Communication from J.F. Sina, Merck Institute for
Therapeutic Research, West Point, PA 19486, Oct. 26, 1982
Volume(issue)/page/year: 26OCT1982
TYPE OF TEST : Cytogenetic analysis
ROUTE OF EXPOSURE : Inhalation
TEST SYSTEM : Rodent - rat
DOSE/DURATION : 5400 ug/m3/16W (Intermittent)
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 25(7),33,1981
TYPE OF TEST : Cytogenetic analysis
ROUTE OF EXPOSURE : Subcutaneous
TEST SYSTEM : Rodent - rat
DOSE/DURATION : 9600 mg/kg/12D (Intermittent)
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 37(10),36,1972
TYPE OF TEST : Micronucleus test
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 200 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 147,294,1985
TYPE OF TEST : Micronucleus test
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 433 ug/kg/24H
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000
Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year:
58,106,1985
*** REVIEWS ***
ACGIH TLV-Not classifiable as a human carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-TWA 188 mg/m3 (50 ppm) (skin)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
IARC Cancer Review:Animal Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 47,79,1989
IARC Cancer Review:Human Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 47,79,1989
IARC Cancer Review:Group 3
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 47,79,1989
TOXICOLOGY REVIEW
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St.,
NW, Washington, DC 20016) V.1- 1960- Volume(issue)/page/year:
22,373,1971
TOXICOLOGY REVIEW
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher
information, see JTCTDW. Volume(issue)/page/year: 11,549,1977
TOXICOLOGY REVIEW
FNSCA6 Forensic Science. (Lausanne, Switzerland) V.1-11, 1972-78. For pub
lisher information, see FSINDR. Volume(issue)/page/year: 2,67,1973
TOXICOLOGY REVIEW
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 47,75,1978
TOXICOLOGY REVIEW
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher
information, see JTCTDW. Volume(issue)/page/year: 11(5),549,1977
TOXICOLOGY REVIEW
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert,
Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued.
Volume(issue)/page/year: 6(1),77,1987
TOXICOLOGY REVIEW
TIHEEC Toxicology and Industrial Health. (Princeton Scientific Pub. Co.,
POB 2155, Princeton, NJ 08540) V.1- 1985- Volume(issue)/page/year:
4,49,1988
TOXICOLOGY REVIEW
NTOTDY Neurobehavioral Toxicology and Teratology. (Fayetteville, NY) V.3-8,
1981-86. For publisher information, see NETEEC. Volume(issue)/page/year:
3,407,1981
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 100 ppm (375 mg/m3) (skin)
DTLWS* "Documentation of the Threshold Limit Values for Substances in
Workroom Air," Supplements. For publisher information, see 85INA8.
Volume(issue)/page/year: 3,29,1973
OSHA PEL (Gen Indu):8H TWA 200 ppm;CL 300;Pk 500/10M
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 200 ppm (750 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 200 ppm (750 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 200 ppm (750 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 100 ppm (375 mg/m3);STEL 150 ppm (560 mg/m3) JAN 1993
OEL-BELGIUM:TWA 100 ppm (377 mg/m3);STEL 150 ppm (565 mg/m3) JAN 1993
OEL-DENMARK:TWA 50 ppm (190 mg/m3);Skin JAN 1993
OEL-FINLAND:TWA 100 ppm (375 mg/m3);STEL 150 ppm;Skin JAN 1993
OEL-FRANCE:TWA 100 ppm (375 mg/m3);STEL 150 ppm (560 mg/m3) JAN 1993
OEL-GERMANY:TWA 100 ppm (380 mg/m3) JAN 1993
OEL-HUNGARY:TWA 100 mg/m3;STEL 300 mg/m3;Skin JAN 1993
OEL-JAPAN:TWA 100 ppm (380 mg/m3) JAN 1993
OEL-THE NETHERLANDS:TWA 100 ppm (375 mg/m3);Skin JAN 1993
OEL-THE PHILIPPINES:TWA 100 ppm (375 mg/m3) JAN 1993
OEL-POLAND:TWA 100 mg/m3 JAN 1993
OEL-RUSSIA:TWA 100 ppm;STEL 50 mg/m3 JAN 1993
OEL-SWEDEN:TWA 50 ppm (200 mg/m3);STEL 100 ppm (400 mg/m3);Skin JAN 1993
OEL-SWITZERLAND:TWA 100 ppm (380 mg/m3);STEL 500 ppm JAN 1993
OEL-THAILAND:TWA 200 ppm;STEL 300 ppm JAN 1993
OEL-TURKEY:TWA 200 ppm (750 mg/m3) JAN 1993
OEL-UNITED KINGDOM:TWA 100 ppm (375 mg/m3);STEL 150 ppm;Skin JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO TOLUENE-air:10H TWA 100 ppm;STEL 150 ppm
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 73300
No. of Facilities: 125516 (estimated)
No. of Industries: 412
No. of Occupations: 206
No. of Employees: 1589482 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 73300
No. of Facilities: 128510 (estimated)
No. of Industries: 399
No. of Occupations: 232
No. of Employees: 2015881 (estimated)
No. of Female Employees: 391255 (estimated)
*** STATUS IN U.S. ***
ATSDR TOXICOLOGY PROFILE
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB/90/198904/AS
EPA GENETOX PROGRAM 1988, Negative: Cell transform.-SA7/SHE; In vitro
SCE-human
EPA GENETOX PROGRAM 1988, Negative: Sperm morphology-mouse
EPA GENETOX PROGRAM 1988, Inconclusive: E coli polA without S9
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year:
47,26992,82
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
NIOSH Analytical Method, 1994: Toluene in blood, 8002
NIOSH Analytical Method, 1994: Hydrocarbons, BP 36-126 degree C, 1500
NIOSH Analytical Method, 1994: Hydrocarbons, aromatic, 1501
NIOSH Analytical Method, 1994: Toluene (passive), 4000
NTP Carcinogenesis Studies (inhalation);no evidence:mouse,rat
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-371,90
*** END OF RECORD ***