*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : XS9140000
CHEMICAL NAME           : Toluene,
                          4-chloro-3-nitro-alpha,alpha,alpha-trifluoro-
CAS REGISTRY NUMBER     : 121-17-5
BEILSTEIN REFERENCE NO. : 0523986
REFERENCE               : 4-05-00-00857 (Beilstein Handbook Reference)
LAST UPDATED            : 199710
DATA ITEMS CITED        : 7
MOLECULAR FORMULA       : C7-H3-Cl-F3-N-O2
MOLECULAR WEIGHT        : 225.56
WISWESSER LINE NOTATION : WNR BG EXFFF
COMPOUND DESCRIPTOR     : Mutagen
SYNONYMS/TRADE NAMES :
   * Benzotrifluoride, 4-chloro-3-nitro-
   * 4-Chloro-3-nitrobenzotrifluoride
   * 4-Chloro-3-nitro-alpha,alpha,alpha-trifluorotoluene
   * 3-Nitro-4-chloro-alpha,alpha,alpha-trifluorotoluene
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1075 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - tremor
   Behavioral - ataxia
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 47(3),88,1982
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 400 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - tremor
   Behavioral - ataxia
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 47(3),88,1982
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 56 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems
   Laboratory, NIOSH Exchange Chemicals.  (Aberdeen Proving Ground, MD 21010)
   Volume(issue)/page/year: NX#07616
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 280 mg/kg/4W-I
TOXIC EFFECTS :
   Brain and Coverings - changes in brain weight
   Liver - changes in liver weight
   Blood - changes in erythrocyte (RBC) count
REFERENCE :
   AISSAW Annali dell'Istituto Superiore di Sanita.  (Istituto Poligrafico e
   Zecca dello Stato, Piazza Verdi, 10 Rome, Italy)  V.1-    1965-
   Volume(issue)/page/year: 19,385,1983
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Human Embryo
DOSE/DURATION           : 1 gm/L
REFERENCE :
   AISSAW Annali dell'Istituto Superiore di Sanita.  (Istituto Poligrafico e
   Zecca dello Stato, Piazza Verdi, 10 Rome, Italy)  V.1-    1965-
   Volume(issue)/page/year: 18,123,1982

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY
   
   EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998

 
                            *** END OF RECORD ***