*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : XS9750000 CHEMICAL NAME : Toluene-2,6-diamine CAS REGISTRY NUMBER : 823-40-5 BEILSTEIN REFERENCE NO. : 2079476 REFERENCE : 3-13-00-00291 (Beilstein Handbook Reference) LAST UPDATED : 199710 DATA ITEMS CITED : 12 MOLECULAR FORMULA : C7-H10-N2 MOLECULAR WEIGHT : 122.19 WISWESSER LINE NOTATION : ZR CZ B1 COMPOUND DESCRIPTOR : Mutagen SYNONYMS/TRADE NAMES : * 1,3-Benzenediamine, 2-methyl- * 2,6-Diaminotoluene * 2,6-Toluylenediamine * 2,6-Tolylenediamine *** HEALTH HAZARD DATA *** ** MUTATION DATA ** TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Bacteria - Salmonella typhimurium DOSE/DURATION : 100 ug/plate REFERENCE : ESKGA2 Eisei Kagaku. Hygienic Chemistry. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1953- Volume(issue)/page/year: 31,113,1985 TYPE OF TEST : Unscheduled DNA synthesis TEST SYSTEM : Human Liver DOSE/DURATION : 10 umol/L REFERENCE : CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 49,1075,1989 TYPE OF TEST : Micronucleus test ROUTE OF EXPOSURE : Oral TEST SYSTEM : Rodent - rat DOSE/DURATION : 300 mg/kg REFERENCE : CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 12,2233,1991 TYPE OF TEST : DNA inhibition ROUTE OF EXPOSURE : Intraperitoneal TEST SYSTEM : Rodent - mouse DOSE/DURATION : 30 mg/kg REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 91,75,1981 TYPE OF TEST : Micronucleus test TEST SYSTEM : Rodent - hamster Ovary DOSE/DURATION : 100 mg/L REFERENCE : EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 26,240,1995 TYPE OF TEST : Cytogenetic analysis TEST SYSTEM : Rodent - hamster Ovary DOSE/DURATION : 10 mmol/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 265,45,1992 *** STATUS IN U.S. *** EPA TSCA Section 8(b) CHEMICAL INVENTORY EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 47,26992,82 EPA TSCA Section 8(d) unpublished health/safety studies EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998 NIOSH Analytical Method, 1994: 2,6-Toluenediamine, 5516 OSHA ANALYTICAL METHOD #ID-65 *** END OF RECORD ***