*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : XO1605800 CHEMICAL NAME : Thioxanthen-9-one, 1-(2-(diethylaminoethyl)amino)-4-methyl-, monohydrochloride CAS REGISTRY NUMBER : 548-57-2 LAST UPDATED : 199707 DATA ITEMS CITED : 14 MOLECULAR FORMULA : C20-H24-N2-O-S.Cl-H MOLECULAR WEIGHT : 376.98 WISWESSER LINE NOTATION : T C666 BS IVJ D1 GM2N2&2 &GH COMPOUND DESCRIPTOR : Drug Mutagen SYNONYMS/TRADE NAMES : * BW 57-233 * CBC 900139 * 1-Diaethylamino-aethylamino-4-methyl-thioxanthonhydrochlorid * 1-(beta-Diethylaminoethylamino)-4-methylthiaxanthone hydrochloride * 1-(2-Diethylaminoethylamino)-4-methylthiaxanthone hydrochloride * 1-((2-Diethylaminoethyl)amino)-4-methylthioxanthen-9-one hydrochloride * DR-15771 * Lucanthone hydrochloride * Lucanthone monohydrochloride * Miracil D * Miracol * Ms. 752 * NIH 3127 * Nilodin * NSC 14574 * 3735 R.P. * Scapuren * Schistosomicide * 79T61 * Thioxanthen-9-one, 1-((2-diethylaminoethyl)amino)-4-methyl-, hydrochloride * 9H-Thioxanthen-9-one, 1-((2-(diethylamino)ethyl)amino)-4-methyl-, monohydrochloride * Tixantone *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 181 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NCISP* National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. (Bethesda, MD 20205) Volume(issue)/page/year: JAN1986 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >500 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : QJPPAL Quarterly Journal of Pharmacy & Pharmacology. (London, UK) V.2-21, 1929-48. For publisher information, see JPPMAB. Volume(issue)/page/year: 20,31,1947 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 45 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : QJPPAL Quarterly Journal of Pharmacy & Pharmacology. (London, UK) V.2-21, 1929-48. For publisher information, see JPPMAB. Volume(issue)/page/year: 20,31,1947 ** MUTATION DATA ** TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Bacteria - Salmonella typhimurium DOSE/DURATION : 28 nmol/L/30M REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 55,43,1978 TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Mold - Neurospora crassa DOSE/DURATION : 75 mg/L/2H REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 55,43,1978 TYPE OF TEST : DNA adduct TEST SYSTEM : Bacteria - Escherichia coli DOSE/DURATION : 10 umol/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 89,95,1981 TYPE OF TEST : Sex chromosome loss and nondisjunction ROUTE OF EXPOSURE : Oral TEST SYSTEM : Insect - Drosophila melanogaster DOSE/DURATION : 2200 umol/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 82,111,1981 TYPE OF TEST : Sex chromosome loss and nondisjunction ROUTE OF EXPOSURE : Parenteral TEST SYSTEM : Insect - Drosophila melanogaster DOSE/DURATION : 2600 umol/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 82,111,1981 TYPE OF TEST : Cytogenetic analysis TEST SYSTEM : Human Cells - not otherwise specified DOSE/DURATION : 10 umol/L REFERENCE : ACIEAY Angewandte Chemie, International Edition in English. (VCH Pub., Inc., 303 NW 12th Ave., Deerfield Beach, FL 33441) V.1- 1962- Volume(issue)/page/year: 10,302,1971 TYPE OF TEST : Cytogenetic analysis TEST SYSTEM : Human Leukocyte DOSE/DURATION : 5 umol/L REFERENCE : ZENBAX Zeitschrift fuer Naturforschung, Teil B: Anorganische Chemie, Organische Chemie, Biochemie, Biophysik, Biologie. (Tuebingen, Fed. Rep. Ger.) V.2B-27B, 1947-1972. For publisher information, see ZNCBDA. Volume(issue)/page/year: 25B,115,1970 TYPE OF TEST : Mutation in mammalian somatic cells TEST SYSTEM : Rodent - mouse Lymphocyte DOSE/DURATION : 1 mg/L/2H REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 59,61,1979 *** STATUS IN U.S. *** EPA GENETOX PROGRAM 1988, Positive: D melanogaster-whole sex chrom. loss EPA GENETOX PROGRAM 1988, Positive: L5178Y cells in vitro-TK test; E coli polA without S9 EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test *** END OF RECORD ***