*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : XO1605800
CHEMICAL NAME           : Thioxanthen-9-one,
                          1-(2-(diethylaminoethyl)amino)-4-methyl-,
                          monohydrochloride
CAS REGISTRY NUMBER     : 548-57-2
LAST UPDATED            : 199707
DATA ITEMS CITED        : 14
MOLECULAR FORMULA       : C20-H24-N2-O-S.Cl-H
MOLECULAR WEIGHT        : 376.98
WISWESSER LINE NOTATION : T C666 BS IVJ D1 GM2N2&2 &GH
COMPOUND DESCRIPTOR     : Drug
                          Mutagen
SYNONYMS/TRADE NAMES :
   * BW 57-233
   * CBC 900139
   * 1-Diaethylamino-aethylamino-4-methyl-thioxanthonhydrochlorid
   * 1-(beta-Diethylaminoethylamino)-4-methylthiaxanthone hydrochloride
   * 1-(2-Diethylaminoethylamino)-4-methylthiaxanthone hydrochloride
   * 1-((2-Diethylaminoethyl)amino)-4-methylthioxanthen-9-one hydrochloride
   * DR-15771
   * Lucanthone hydrochloride
   * Lucanthone monohydrochloride
   * Miracil D
   * Miracol
   * Ms. 752
   * NIH 3127
   * Nilodin
   * NSC 14574
   * 3735 R.P.
   * Scapuren
   * Schistosomicide
   * 79T61
   * Thioxanthen-9-one, 1-((2-diethylaminoethyl)amino)-4-methyl-,  
   hydrochloride
   * 9H-Thioxanthen-9-one, 1-((2-(diethylamino)ethyl)amino)-4-methyl-,  
   monohydrochloride
   * Tixantone
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 181 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NCISP* National Cancer Institute Screening Program Data Summary,
   Developmental Therapeutics Program. (Bethesda, MD 20205)
   Volume(issue)/page/year: JAN1986
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   QJPPAL Quarterly Journal of Pharmacy & Pharmacology.  (London, UK)  V.2-21,
   1929-48.  For publisher information, see JPPMAB.  Volume(issue)/page/year:
   20,31,1947
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 45 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   QJPPAL Quarterly Journal of Pharmacy & Pharmacology.  (London, UK)  V.2-21,
   1929-48.  For publisher information, see JPPMAB.  Volume(issue)/page/year:
   20,31,1947
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 28 nmol/L/30M
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 55,43,1978
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Mold - Neurospora crassa
DOSE/DURATION           : 75 mg/L/2H
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 55,43,1978
 
TYPE OF TEST            : DNA adduct
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 10 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 89,95,1981
 
TYPE OF TEST            : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Insect - Drosophila melanogaster
DOSE/DURATION           : 2200 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 82,111,1981
 
TYPE OF TEST            : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE       : Parenteral
TEST SYSTEM             : Insect - Drosophila melanogaster
DOSE/DURATION           : 2600 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 82,111,1981
 
TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Human Cells - not otherwise specified
DOSE/DURATION           : 10 umol/L
REFERENCE :
   ACIEAY Angewandte Chemie, International Edition in English.  (VCH Pub.,
   Inc., 303 NW 12th Ave., Deerfield Beach, FL 33441)  V.1-    1962-
   Volume(issue)/page/year: 10,302,1971
 
TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Human Leukocyte
DOSE/DURATION           : 5 umol/L
REFERENCE :
   ZENBAX Zeitschrift fuer Naturforschung, Teil B: Anorganische Chemie,
   Organische Chemie, Biochemie, Biophysik, Biologie.  (Tuebingen, Fed. Rep.
   Ger.)  V.2B-27B, 1947-1972.  For publisher information, see ZNCBDA.
   Volume(issue)/page/year: 25B,115,1970
 
TYPE OF TEST            : Mutation in mammalian somatic cells
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 1 mg/L/2H
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 59,61,1979

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Positive: D melanogaster-whole sex chrom. loss
   
   EPA GENETOX PROGRAM 1988, Positive: L5178Y cells in vitro-TK test; E coli
   polA without S9
   
   EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test

 
                            *** END OF RECORD ***