*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : XT5075000
CHEMICAL NAME           : p-Toluenesulfonamide
CAS REGISTRY NUMBER     : 70-55-3
BEILSTEIN REFERENCE NO. : 0472689
REFERENCE               : 4-11-00-00376 (Beilstein Handbook Reference)
LAST UPDATED            : 199710
DATA ITEMS CITED        : 10
MOLECULAR FORMULA       : C7-H9-N-O2-S
MOLECULAR WEIGHT        : 171.23
WISWESSER LINE NOTATION : ZSWR D1
COMPOUND DESCRIPTOR     : Drug
                          Mutagen
SYNONYMS/TRADE NAMES :
   * Benzenesulfonamide, 4-methyl-
   * p-Methylbenzenesulfonamide
   * 4-Methylbenzenesulfonamide
   * p-Toluenesulfanamide
   * 4-Toluenesulfanamide
   * Toluene-4-sulfonamide
   * p-Toluenesulfonylamide
   * Toluene-p-sulphonamide
   * Tolylsulfonamide
   * p-Tolylsulfonamide
   * Tosylamide
   * p-Tosylamide
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 250 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: AD691-490
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 2 gm/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - excitement
   Behavioral - muscle weakness
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 14,259,1920
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Bird - wild bird species
DOSE/DURATION           : 75 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   21,315,1972
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 40 umol/plate
REFERENCE :
   45OHAA "Short-Term Test Systems for Detecting Carcinogens, Proceedings of
   the Symposium, 1978," Norpoth, K.H., and R.G. Garner, eds., Berlin,
   Springer-Verlag, 1980  Volume(issue)/page/year: -,170,1980
 
TYPE OF TEST            : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Insect - Drosophila melanogaster
DOSE/DURATION           : 2500 umol/plate
REFERENCE :
   45OHAA "Short-Term Test Systems for Detecting Carcinogens, Proceedings of
   the Symposium, 1978," Norpoth, K.H., and R.G. Garner, eds., Berlin,
   Springer-Verlag, 1980  Volume(issue)/page/year: -,170,1980

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - A1329
       No. of Facilities: 195 (estimated)
       No. of Industries: 5
       No. of Occupations: 29
       No. of Employees: 4613 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - A1329
       No. of Facilities: 304 (estimated)
       No. of Industries: 8
       No. of Occupations: 16
       No. of Employees: 9023 (estimated)
       No. of Female Employees: 1223 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
   
   EPA TSCA Section 8(b) CHEMICAL INVENTORY
   
   EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998

 
                            *** END OF RECORD ***