*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : XT5075000 CHEMICAL NAME : p-Toluenesulfonamide CAS REGISTRY NUMBER : 70-55-3 BEILSTEIN REFERENCE NO. : 0472689 REFERENCE : 4-11-00-00376 (Beilstein Handbook Reference) LAST UPDATED : 199710 DATA ITEMS CITED : 10 MOLECULAR FORMULA : C7-H9-N-O2-S MOLECULAR WEIGHT : 171.23 WISWESSER LINE NOTATION : ZSWR D1 COMPOUND DESCRIPTOR : Drug Mutagen SYNONYMS/TRADE NAMES : * Benzenesulfonamide, 4-methyl- * p-Methylbenzenesulfonamide * 4-Methylbenzenesulfonamide * p-Toluenesulfanamide * 4-Toluenesulfanamide * Toluene-4-sulfonamide * p-Toluenesulfonylamide * Toluene-p-sulphonamide * Tolylsulfonamide * p-Tolylsulfonamide * Tosylamide * p-Tosylamide *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 250 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD691-490 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 2 gm/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - excitement Behavioral - muscle weakness REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 14,259,1920 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Bird - wild bird species DOSE/DURATION : 75 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 21,315,1972 ** MUTATION DATA ** TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Bacteria - Salmonella typhimurium DOSE/DURATION : 40 umol/plate REFERENCE : 45OHAA "Short-Term Test Systems for Detecting Carcinogens, Proceedings of the Symposium, 1978," Norpoth, K.H., and R.G. Garner, eds., Berlin, Springer-Verlag, 1980 Volume(issue)/page/year: -,170,1980 TYPE OF TEST : Sex chromosome loss and nondisjunction ROUTE OF EXPOSURE : Oral TEST SYSTEM : Insect - Drosophila melanogaster DOSE/DURATION : 2500 umol/plate REFERENCE : 45OHAA "Short-Term Test Systems for Detecting Carcinogens, Proceedings of the Symposium, 1978," Norpoth, K.H., and R.G. Garner, eds., Berlin, Springer-Verlag, 1980 Volume(issue)/page/year: -,170,1980 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - A1329 No. of Facilities: 195 (estimated) No. of Industries: 5 No. of Occupations: 29 No. of Employees: 4613 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - A1329 No. of Facilities: 304 (estimated) No. of Industries: 8 No. of Occupations: 16 No. of Employees: 9023 (estimated) No. of Female Employees: 1223 (estimated) *** STATUS IN U.S. *** EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal EPA TSCA Section 8(b) CHEMICAL INVENTORY EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998 *** END OF RECORD ***