*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : XU1594000
CHEMICAL NAME           : p-Toluic acid, 3-bis(2-chloroethyl)amino-
CAS REGISTRY NUMBER     : 5977-35-5
BEILSTEIN REFERENCE NO. : 2813306
LAST UPDATED            : 199707
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C12-H15-Cl2-N-O2
MOLECULAR WEIGHT        : 276.18
WISWESSER LINE NOTATION : QVR D1 CN2G2G
COMPOUND DESCRIPTOR     : Drug
                          Mutagen
SYNONYMS/TRADE NAMES :
   * Alkyrom
   * Benzoic acid, 3-bis(2-chloroethyl)amino-4-methyl-
   * 3-Bis(2-chloroethyl)amino-4-methylbenzoic acid
   * 3-Bis(2-chloroethyl)amino-p-toluic acid
   * IOB 82
   * NSC-1461711
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 17 mg/kg
TOXIC EFFECTS :
   Behavioral - food intake (animal)
   Gastrointestinal - nausea or vomiting
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   CCROBU Cancer Chemotherapy Reports, Part 1.  (Washington, DC)  V.52(6)-59,
   1968-75.  For publisher information, see CTRRDO.  Volume(issue)/page/year:
   54,319,1970
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 17 mg/kg
TOXIC EFFECTS :
   Tumorigenic - active as anti-cancer agent
REFERENCE :
   NEOLA4 Neoplasma.  (Karger-Libri, P.O. Box, CH-4009 Basel, Switzerland) V.4-
      1957-  Volume(issue)/page/year: 27,271,1980
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Human Leukocyte
DOSE/DURATION           : 300 ug/L
REFERENCE :
   CCROBU Cancer Chemotherapy Reports, Part 1.  (Washington, DC)  V.52(6)-59,
   1968-75.  For publisher information, see CTRRDO.  Volume(issue)/page/year:
   57,29,1973

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Positive: In vitro cytogenetics-human lymphocyte
   
   EPA GENETOX PROGRAM 1988, Positive: In vivo cytogenetics-human lymphocyte

 
                            *** END OF RECORD ***