*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : XU8225000
CHEMICAL NAME           : o-Toluidine, 5-nitro-
CAS REGISTRY NUMBER     : 99-55-8
BEILSTEIN REFERENCE NO. : 0879021
REFERENCE               : 4-12-00-01807 (Beilstein Handbook Reference)
LAST UPDATED            : 199701
DATA ITEMS CITED        : 14
MOLECULAR FORMULA       : C7-H8-N2-O2
MOLECULAR WEIGHT        : 152.17
WISWESSER LINE NOTATION : ZR B1 ENW
COMPOUND DESCRIPTOR     : Tumorigen
                          Mutagen
SYNONYMS/TRADE NAMES :
   * Amarthol Fast Scarlet G Base
   * Amarthol Fast Scarlet G salt
   * 1-Amino-2-methyl-5-nitrobenzene
   * 2-Amino-4-nitrotoluene
   * Azoene Fast Scarlet GC Base
   * Azoene Fast Scarlet GC salt
   * Azofix Scarlet G salt
   * Azogene Fast Scarlet G
   * Azoic Diazo Component 12
   * Benzenamine, 2-methyl-5-nitro-
   * C.I. 37105
   * C.I. Azoic Diazo Component 12
   * Dainichi Fast Scarlet G Base
   * Daito Scarlet Base G
   * Devol Scarlet B
   * Devol Scarlet G salt
   * Diabase Scarlet G
   * Diazo Fast Scarlet G
   * Fast Red SG Base
   * Fast Scarlet Base G
   * Fast Scarlet Base J
   * Fast Scarlet G
   * Fast Scarlet G Base
   * Fast Scarlet GC Base
   * Fast Scarlet G salt
   * Fast Scarlet J salt
   * Fast Scarlet M4NT Base
   * Fast Scarlet T Base
   * Hiltonil Fast Scarlet G Base
   * Hiltonil Fast Scarlet GC Base
   * Hiltonil Fast Scarlet G salt
   * Kayaku Scarlet G Base
   * Lake Scarlet G Base
   * Lithosol Orange R Base
   * 2-Methyl-5-nitroaniline
   * 6-Methyl-3-nitroaniline
   * 2-Methyl-5-nitro-benzeneamine
   * Mitsui Scarlet G Base
   * Naphthanil Scarlet G Base
   * Naphtoelan Fast Scarlet G Base
   * Naphtoelan Fast Scarlet G Salt
   * NCI-C01843
   * 4-Nitro-2-aminotoluene
   * 3-Nitro-6-methylaniline
   * 5-Nitro-2-methylaniline
   * 5-Nitro-o-toluidine
   * 5-Nitro-2-toluidine
   * PNOT
   * RCRA waste number U181
   * Scarlet Base Ciba II
   * Scarlet Base IRGA II
   * Scarlet Base NSP
   * Scarlet G Base
   * Sugai Fast Scarlet G base
   * Symulon Scarlet G Base
 
                       *** HEALTH HAZARD DATA ***
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 150 gm/kg/78W-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Vascular - tumors
   Liver - tumors
REFERENCE :
   NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
   (Bethesda, MD)  No.0-205. For publisher information, see NTPTR*.
   Volume(issue)/page/year: NCI-TR-107,1978
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 10 ug/plate
REFERENCE :
   ENMUDM Environmental Mutagenesis.  (New York, NY)  V.1-9, 1979-87.  For
   publisher information, see EMMUEG.  Volume(issue)/page/year: 4,163,1982
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 33300 ng/plate
REFERENCE :
   ENMUDM Environmental Mutagenesis.  (New York, NY)  V.1-9, 1979-87.  For
   publisher information, see EMMUEG.  Volume(issue)/page/year: 7(Suppl
   5),1,1985
 
TYPE OF TEST            : Morphological transformation
TEST SYSTEM             : Rodent - rat Embryo
DOSE/DURATION           : 41 ug/plate
REFERENCE :
   JJATDK JAT, Journal of Applied Toxicology.  (John Wiley & Sons Ltd., Baffins
   Lane, Chichester, W. Sussex PO19 1UD, UK)  V.1-    1981-
   Volume(issue)/page/year: 1,190,1981
 
TYPE OF TEST            : Morphological transformation
TEST SYSTEM             : Rodent - mouse Embryo
DOSE/DURATION           : 160 ug/L
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   12,21,1988

                              *** REVIEWS ***
 
   IARC Cancer Review:Animal Limited Evidence
   IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
   to Man.  (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
   V.1-    1972-  Volume(issue)/page/year: 48,169,1990

   IARC Cancer Review:Group 3
   IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
   to Man.  (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
   V.1-    1972-  Volume(issue)/page/year: 48,169,1990

                    *** OCCUPATIONAL EXPOSURE LIMITS ***
 
   OEL-GERMANY;Carcinogen JAN 1993
   
   OEL-SWITZERLAND;Carcinogen JAN 1993

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - X1540
       No. of Facilities: 41 (estimated)
       No. of Industries: 2
       No. of Occupations: 3
       No. of Employees: 13741 (estimated)
       No. of Female Employees: 12621 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY
   
   EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
   
   NCI Carcinogenesis Bioassay (feed);clear evidence:mouse
   NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
   (Bethesda, MD)  No.0-205. For publisher information, see NTPTR*.
   Volume(issue)/page/year: NCI-TR-107,78

   NCI Carcinogenesis Bioassay (feed);no evidence:rat
   NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
   (Bethesda, MD)  No.0-205. For publisher information, see NTPTR*.
   Volume(issue)/page/year: NCI-TR-107,78

 
                            *** END OF RECORD ***