*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : XX9450000
CHEMICAL NAME : 1,3,5,2,4,6-Triazatriphosphorine,
2,2,4,4,6,6-hexakis(1-aziridinyl)-2,2,4,4,6,6-hexahyd
ro-
CAS REGISTRY NUMBER : 52-46-0
BEILSTEIN REFERENCE NO. : 1334691
REFERENCE : 5-20-01-00125 (Beilstein Handbook Reference)
LAST UPDATED : 199710
DATA ITEMS CITED : 42
MOLECULAR FORMULA : C12-H24-N9-P3
MOLECULAR WEIGHT : 387.36
WISWESSER LINE NOTATION : T6NPNPNPJ B- AT3NTJ& B- AT3NTJ& D- AT3NTJ& D- AT3NTJ&
F- AT3NTJ& F- AT3NTJ
COMPOUND DESCRIPTOR : Agricultural Chemical
Tumorigen
Drug
Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Afolat
* Apholate
* APN
* Aziridine, 1,3,5,2,4,6-triazatriphosphorine derivative
* 1-Aziridinylphosphonitrile trimer
* ENT 26,316
* Hexa(1-aziridinyl)triphosphotriazine
* 2,2,4,4,6,6-Hexahydro-2,2,4,4,6,6-hexakis(1-aziridinyl)-1,3,5,2,4,6-tria
zatriphosphorine
* 2,2,4,4,6,6-Hexakis(1-aziridinyl)cyclotriphosphaza-1,3,5-triene
* 2,2,4,4,6,6-Hexakis(1-aziridinyl)-2,2,4,4,6,6-hexahydro-1,3,5,2,4,6-tria
zatriphosphorine
* Hexakis-(1-aziridinyl)phosphonitrile
* Hexakis(aziridinyl)phosphotriazine
* NSC-26812
* Olin MO. 2174
* Pholate
* PN6
* SQ 8388
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 98 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
14,515,1969
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BWHOA6 Bulletin of the World Health Organization. (WHO, Pub. Center USA, 49
Sheridan Ave., Albany, NY 12210) Volume(issue)/page/year: 31,737,1964
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 21 mg/kg
TOXIC EFFECTS :
Liver - hepatitis (hepatocellular necrosis), zonal
Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
acute tubular necrosis)
Blood - changes in spleen
REFERENCE :
FATOBP Farmakologiya i Toksikologiya (Kiev). Pharmacology and Toxicology.
(Kievskii Nauchno- Issledovatel'skii Institut Farmakologii i Toksikologii,
Kiev, USSR) No.1- 1964- Volume(issue)/page/year: 8,73,1973
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 110 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc.,
Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC
20037) V.1- 1953- Volume(issue)/page/year: 14,301,1966
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 50 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc.,
Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
20037) V.6- 1963- Volume(issue)/page/year: 29,1341,1986
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 25 mg/kg
TOXIC EFFECTS :
Liver - hepatitis (hepatocellular necrosis), zonal
Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
acute tubular necrosis)
Blood - changes in spleen
REFERENCE :
FATOBP Farmakologiya i Toksikologiya (Kiev). Pharmacology and Toxicology.
(Kievskii Nauchno- Issledovatel'skii Institut Farmakologii i Toksikologii,
Kiev, USSR) No.1- 1964- Volume(issue)/page/year: 8,73,1973
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 2900 ug/kg
TOXIC EFFECTS :
Liver - hepatitis (hepatocellular necrosis), zonal
Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
acute tubular necrosis)
Blood - changes in spleen
REFERENCE :
FATOBP Farmakologiya i Toksikologiya (Kiev). Pharmacology and Toxicology.
(Kievskii Nauchno- Issledovatel'skii Institut Farmakologii i Toksikologii,
Kiev, USSR) No.1- 1964- Volume(issue)/page/year: 8,73,1973
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Bird - chicken
DOSE/DURATION : 246 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
(usually neuromuscular blockage)
Behavioral - food intake (animal)
Behavioral - ataxia
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
9,279,1966
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Bird - quail
DOSE/DURATION : 179 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
(usually neuromuscular blockage)
Behavioral - food intake (animal)
Behavioral - ataxia
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
9,279,1966
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - domestic
DOSE/DURATION : 50 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Gastrointestinal - hypermotility, diarrhea
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
ANYAA9 Annals of the New York Academy of Sciences. (New York Academy of
Sciences, 2 E. 63rd St., New York, NY 10021) V.1- 1877-
Volume(issue)/page/year: 111,715,1964
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Mammal - domestic
DOSE/DURATION : 5 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Gastrointestinal - hypermotility, diarrhea
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
ANYAA9 Annals of the New York Academy of Sciences. (New York Academy of
Sciences, 2 E. 63rd St., New York, NY 10021) V.1- 1877-
Volume(issue)/page/year: 111,715,1964
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Bird - wild bird species
DOSE/DURATION : 246 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
(usually neuromuscular blockage)
Behavioral - food intake (animal)
Behavioral - ataxia
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
9,279,1966
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Bird - domestic
DOSE/DURATION : 179 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
(usually neuromuscular blockage)
Behavioral - food intake (animal)
Behavioral - ataxia
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
9,279,1966
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1470 mg/kg/98D-C
TOXIC EFFECTS :
Related to Chronic Data - death
REFERENCE :
BWHOA6 Bulletin of the World Health Organization. (WHO, Pub. Center USA, 49
Sheridan Ave., Albany, NY 12210) Volume(issue)/page/year: 31,721,1964
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Bird - chicken
DOSE/DURATION : 42875 mg/kg/15W-I
TOXIC EFFECTS :
Blood - changes in leukocyte (WBC) count
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Related to Chronic Data - death
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
9,279,1966
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 105 mg/kg
SEX/DURATION : male 21 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 12,199,1982
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE : 10 mg/kg
SEX/DURATION : female 11 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - extra-embryonic structures
(e.g., placenta, umbilical cord)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St.,
NW, Washington, DC 20016) V.1- 1960- Volume(issue)/page/year:
16,805,1968
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE : 10 mg/kg
SEX/DURATION : male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - male fertility index (e.g. # males impregnating
females per # males exposed to fertile nonpregnant females)
REFERENCE :
85GUAJ "Antifertility Compounds in the Male and Female," Jackson, H.,
Springfield, IL, Charles C. Thomas, 1966 Volume(issue)/page/year: -,37,1966
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE : 5 mg/kg
SEX/DURATION : male 5 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - male fertility index (e.g. # males impregnating
females per # males exposed to fertile nonpregnant females)
Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
before birth)
REFERENCE :
EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel,
Switzerland) V.1- 1945- Volume(issue)/page/year: 24,924,1968
** MUTATION DATA **
TYPE OF TEST : Cytogenetic analysis
ROUTE OF EXPOSURE : Parenteral
TEST SYSTEM : Insect - grasshopper
DOSE/DURATION : 100 ug
REFERENCE :
CYTOAN Cytologia. (Japan Pub. Trading Co. (USA), 1255 Howard St., San
Francisco, CA 94103) V.1- 1929- Volume(issue)/page/year: 34,405,1969
TYPE OF TEST : Mutation test systems - not otherwise specified
ROUTE OF EXPOSURE : Administration onto the skin
TEST SYSTEM : Insect - not otherwise specified
DOSE/DURATION : 100 ppm
REFERENCE :
CYTOAN Cytologia. (Japan Pub. Trading Co. (USA), 1255 Howard St., San
Francisco, CA 94103) V.1- 1929- Volume(issue)/page/year: 38,21,1973
TYPE OF TEST : Cytogenetic analysis
ROUTE OF EXPOSURE : Parenteral
TEST SYSTEM : Insect - not otherwise specified
DOSE/DURATION : 300 ug
REFERENCE :
ABABAC Annales de Biologie Animale, Biochimie, Biophysique. (Versailles,
France) V.1-19, 1961-79. Volume(issue)/page/year: 17,661,1977
TYPE OF TEST : Cytogenetic analysis
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Insect - not otherwise specified
DOSE/DURATION : 500 ppm
REFERENCE :
ABABAC Annales de Biologie Animale, Biochimie, Biophysique. (Versailles,
France) V.1-19, 1961-79. Volume(issue)/page/year: 17,661,1977
TYPE OF TEST : Cytogenetic analysis
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Insect - not otherwise specified
DOSE/DURATION : 10 ppm
REFERENCE :
ABABAC Annales de Biologie Animale, Biochimie, Biophysique. (Versailles,
France) V.1-19, 1961-79. Volume(issue)/page/year: 17,661,1977
TYPE OF TEST : Cytogenetic analysis
ROUTE OF EXPOSURE : Administration onto the skin
TEST SYSTEM : Insect - not otherwise specified
DOSE/DURATION : 10 ppm
REFERENCE :
CYTOAN Cytologia. (Japan Pub. Trading Co. (USA), 1255 Howard St., San
Francisco, CA 94103) V.1- 1929- Volume(issue)/page/year: 29,346,1964
TYPE OF TEST : Cytogenetic analysis
ROUTE OF EXPOSURE : Administration onto the skin
TEST SYSTEM : Insect - not otherwise specified
DOSE/DURATION : 10 ppm
REFERENCE :
CYTOAN Cytologia. (Japan Pub. Trading Co. (USA), 1255 Howard St., San
Francisco, CA 94103) V.1- 1929- Volume(issue)/page/year: 38,21,1973
TYPE OF TEST : Dominant lethal test
ROUTE OF EXPOSURE : Parenteral
TEST SYSTEM : Insect - not otherwise specified
DOSE/DURATION : 2700 ng
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 7,63,1969
TYPE OF TEST : Dominant lethal test
ROUTE OF EXPOSURE : Unreported
TEST SYSTEM : Insect - not otherwise specified
DOSE/DURATION : 5 ppm
REFERENCE :
BWHOA6 Bulletin of the World Health Organization. (WHO, Pub. Center USA, 49
Sheridan Ave., Albany, NY 12210) Volume(issue)/page/year: 47,305,1972
TYPE OF TEST : Dominant lethal test
ROUTE OF EXPOSURE : Parenteral
TEST SYSTEM : Insect - not otherwise specified
DOSE/DURATION : 2500 ng
REFERENCE :
BEREA2 Bulletin of Entomological Research. (CAB International, Central
Sales, Farnham House, Farnham Royal, Slough SL2 3BN, UK) V.1- 1910-
Volume(issue)/page/year: 62,401,1973
TYPE OF TEST : Sperm Morphology
ROUTE OF EXPOSURE : Unreported
TEST SYSTEM : Insect - not otherwise specified
DOSE/DURATION : 20 ppm
REFERENCE :
CYTBAI Cytobios. (Faculty Press, 88 Regent St., Cambridge, UK) V.1- 1969-
Volume(issue)/page/year: 12,45,1975
TYPE OF TEST : Sperm Morphology
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Insect - Drosophila melanogaster
DOSE/DURATION : 1 pph
REFERENCE :
ABABAC Annales de Biologie Animale, Biochimie, Biophysique. (Versailles,
France) V.1-19, 1961-79. Volume(issue)/page/year: 17,661,1977
TYPE OF TEST : Sperm Morphology
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Insect - not otherwise specified
DOSE/DURATION : 500 ppm
REFERENCE :
ABABAC Annales de Biologie Animale, Biochimie, Biophysique. (Versailles,
France) V.1-19, 1961-79. Volume(issue)/page/year: 17,661,1977
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Human Leukocyte
DOSE/DURATION : 100 umol/L
REFERENCE :
CHROAU Chromosoma. (Springer-Verlag New York, Inc., Service Center, 44
Hartz Way, Secaucus, NJ 07094) V.1- 1939- Volume(issue)/page/year:
24,314,1968
TYPE OF TEST : DNA inhibition
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - rat
DOSE/DURATION : 5 mg/kg
REFERENCE :
IJEBA6 Indian Journal of Experimental Biology. (Publications & Information
Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
Volume(issue)/page/year: 16,720,1978
TYPE OF TEST : Cytogenetic analysis
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - rat
DOSE/DURATION : 500 ug/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 141,175,1984
TYPE OF TEST : Sister chromatid exchange
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - rat
DOSE/DURATION : 500 ug/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 141,175,1984
TYPE OF TEST : Cytogenetic analysis
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 15 mg/kg
REFERENCE :
PISCAD Proceedings of the Indian Science Congress. (Indian Science Congress
Assoc., 14, Dr. Biresh Guha St., Calcutta, 700017, India) 1st- 1914-
Volume(issue)/page/year: 59(Pt 3),417,1972
*** REVIEWS ***
IARC Cancer Review:Animal Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 9,31,1975
IARC Cancer Review:Human No Adequate Data
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 9,31,1975
IARC Cancer Review:Group 3
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year:
7,56,1987
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: N crassa-forward mutation
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
*** END OF RECORD ***