*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : XY1450000
CHEMICAL NAME           : Triazene, 3,3-dimethyl-1-(p-nitrophenyl)-
CAS REGISTRY NUMBER     : 7227-92-1
LAST UPDATED            : 199410
DATA ITEMS CITED        : 7
MOLECULAR FORMULA       : C8-H10-N4-O2
MOLECULAR WEIGHT        : 194.22
WISWESSER LINE NOTATION : WNR DNUNN1&1
COMPOUND DESCRIPTOR     : Tumorigen
                          Mutagen
SYNONYMS/TRADE NAMES :
   * 3,3-Dimethyl-1-(p-nitrophenyl)triazene
   * 1-p-Nitrofenyl-3,3-dimethyltriazen
   * 1-(p-Nitrophenyl)-3,3-dimethyl-triazen
   * 1-(p-Nitrophenyl)-3,3-dimethyl-triazene
   * 1-(4-Nitrophenyl)-3,3-dimethyltriazene
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1664 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - structural or functional change in trachea
   or bronchi
   Gastrointestinal - ulceration or bleeding from stomach
   Liver - other changes
REFERENCE :
   PHBOBQ Physiologia Bohemoslovaca.  (Academic Press Inc. Ltd., 24-28 Oval
   Rd., London NW1 7DX, UK) V.15-    1966-  Volume(issue)/page/year: 21,63,1972
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 350 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ZKKOBW Zeitschrift fuer Krebsforschung und Klinische Onkologie.  (Berlin,
   Fed. Rep. Ger.)  V.76-92, 1971-78.  For publisher information, see JCROD7.
   Volume(issue)/page/year: 81,285,1974
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 3250 mg/kg/72W-I
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Brain and Coverings - tumors
   Peripheral Nerve and Sensation - peripheral nerve tumors
REFERENCE :
   ZKKOBW Zeitschrift fuer Krebsforschung und Klinische Onkologie.  (Berlin,
   Fed. Rep. Ger.)  V.76-92, 1971-78.  For publisher information, see JCROD7.
   Volume(issue)/page/year: 81,285,1974
 
TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 330 mg/kg
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Peripheral Nerve and Sensation - peripheral nerve tumors
REFERENCE :
   ZKKOBW Zeitschrift fuer Krebsforschung und Klinische Onkologie.  (Berlin,
   Fed. Rep. Ger.)  V.76-92, 1971-78.  For publisher information, see JCROD7.
   Volume(issue)/page/year: 81,285,1974
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 300 nmol/plate
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 190,177,1987
 
TYPE OF TEST            : DNA repair
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 100 mmol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 190,177,1987
 
TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 1 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 190,183,1987
 
                            *** END OF RECORD ***