*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : XY4390000 CHEMICAL NAME : s-Triazine, 2,4-bis(isopropylamino)-6-(methylthio)- CAS REGISTRY NUMBER : 7287-19-6 OTHER CAS REGISTRY NOS. : 83653-07-0 BEILSTEIN REFERENCE NO. : 0613575 LAST UPDATED : 199710 DATA ITEMS CITED : 15 MOLECULAR FORMULA : C10-H19-N5-S MOLECULAR WEIGHT : 241.40 WISWESSER LINE NOTATION : T6N CN ENJ BS1 DMY1&1 FMY1&1 COMPOUND DESCRIPTOR : Agricultural Chemical Mutagen Reproductive Effector Primary Irritant SYNONYMS/TRADE NAMES : * 2,4-Bis(isopropylamino)-6-methyl mercapto-s-triazine * 2,4-Bis(isopropylamino)-6-methylthio-s-triazine * 2,4-Bis(isopropylamino)-6-methylthio-1,3,5-triazine * N,N'-Bis(1-methylethyl)-6-methyl-thio-1,3,5-triazine-2,4-diamine * 2,4-Bis(propylamino)-6-methylthio-1,3,5-triazin * Caparol * N,N'-Diisopropyl-6-methylthio-1,3,5-triazine-2,4-diyldiamine * G 34161 * Gesagard * Mercazin * Merkazin * 2-Methylmercapto-4,6-bis(isopropylamino)-s-triazine * 2-Methylthio-4,6-bis(isopropylamino)-s-triazine * Polisin * Primatol Q * Promepin * Promethryn * Prometrene * Prometrex * Prometrin * Prometryn * Prometryne * Selectin * Selektin * Sesagard * s-Triazine, 4,6-bis(isopropylamino)-2-methylmercapto- * 1,3,5-Triazine-2,4-diamine, N,N'-bis(1-methylethyl)-6-(methylthio)- * Uvon *** HEALTH HAZARD DATA *** ** SKIN/EYE IRRITATION DATA ** TYPE OF TEST : Standard Draize test ROUTE OF EXPOSURE : Administration into the eye SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 80 mg REACTION SEVERITY : Mild REFERENCE : CIGET* Ciba-Geigy Toxicology Data/Indexes. (Ciba-Geigy Corp., 556 Morris Ave., Summit, NJ 07901) Volume(issue)/page/year: -,-,1977 ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 2100 mg/kg TOXIC EFFECTS : Autonomic Nervous System - other (direct) parasympathomimetic Lungs, Thorax, or Respiration - other changes Gastrointestinal - other changes REFERENCE : GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 34(3),94,1969 TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >2430 mg/m3/4H TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85JFAN "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc. of Chemistry, 1983-86 Volume(issue)/page/year: A340,1983 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >3100 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,711,1991 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 2138 mg/kg TOXIC EFFECTS : Behavioral - muscle weakness Lungs, Thorax, or Respiration - respiratory depression Kidney, Ureter, Bladder - urine volume increased REFERENCE : GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 33(2),12,1968 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : >3100 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094) Volume(issue)/page/year: -,C250,1991 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Mammal - species unspecified DOSE/DURATION : 1800 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 44(6),81,1979 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 14223 mg/kg/7W-I TOXIC EFFECTS : Liver - changes in liver weight Endocrine - changes in adrenal weight Blood - other changes REFERENCE : GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 33(2),12,1968 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE : 2400 mg/kg SEX/DURATION : female 18-20 day(s) after conception lactating female 2-4 day(s) post-birth TOXIC EFFECTS : Reproductive - Effects on Newborn - behavioral Reproductive - Effects on Newborn - physical Reproductive - Effects on Newborn - delayed effects REFERENCE : ZHYGAM Zeitschrift fuer die Gesamte Hygiene und Ihre Grenzgebiete. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1955- Volume(issue)/page/year: 34,116,1988 ** MUTATION DATA ** TYPE OF TEST : Gene conversion and mitotic recombination TEST SYSTEM : Yeast - Saccharomyces cerevisiae DOSE/DURATION : 500 ug/L REFERENCE : CYGEDX Cytology and Genetics (English Translation). Translation of TGANAK. (Allerton Press Inc., 150 Fifth Ave., New York, NY 10011) V.8- 1974- Volume(issue)/page/year: 21(2),59,1987 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M3180 No. of Facilities: 167 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 1169 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M3180 No. of Facilities: 13 (estimated) No. of Industries: 1 No. of Occupations: 9 No. of Employees: 567 (estimated) No. of Female Employees: 13 (estimated) *** STATUS IN U.S. *** On EPA IRIS database EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998 *** END OF RECORD ***