*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : XY5850700
CHEMICAL NAME           : 1,2,4-Triazine-3,5-diamine, 6-(2,3-dichlorophenyl)-
CAS REGISTRY NUMBER     : 84057-84-1
LAST UPDATED            : 199706
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C9-H7-Cl2-N5
MOLECULAR WEIGHT        : 256.11
COMPOUND DESCRIPTOR     : Drug
                          Human
SYNONYMS/TRADE NAMES :
   * BW 430C
   * 3,5-Diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine
   * 6-(2,3-Dichlorophenyl)-1,2,4-triazine-3,5-diamine
   * Lamictal
   * Lamotrigine
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 19 mg/kg
TOXIC EFFECTS :
   Behavioral - muscle contraction or spasticity
   Sense Organs and Special Senses (Eye) - effect, not otherwise specified
   Cardiac - EKG changes not diagnostic of specified effects
REFERENCE :
   LANCAO Lancet.  (7 Adam St., London WC2N 6AD, UK)  V.1-    1823-
   Volume(issue)/page/year: 342,1552,1993
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 2 mg/kg/30H-I
TOXIC EFFECTS :
   Gastrointestinal - nausea or vomiting
   Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
   acute tubular necrosis)
REFERENCE :
   PEDIAU Pediatrics.  (American Academy of Pediatrics, P.O. Box 1034,
   Evanston, IL 60204) V.1-    1948-  Volume(issue)/page/year: 98,294,1996
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 205 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   EPILAK Epilepsia (New York).  (Raven Press, 1185 Ave. of the Americas, New
   York, NY 10036) Ser.1-3: 1909-55; Ser.4: V.1-    1959-
   Volume(issue)/page/year: 25,655,1984
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 245 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   EPILAK Epilepsia (New York).  (Raven Press, 1185 Ave. of the Americas, New
   York, NY 10036) Ser.1-3: 1909-55; Ser.4: V.1-    1959-
   Volume(issue)/page/year: 25,655,1984
 
                            *** END OF RECORD ***