*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : XY8577000 CHEMICAL NAME : as-Triazine-3,5-(2H,4H)-dione, 2-(2',3',5'-triacetyl-beta-D-ribofuranosyl)- CAS REGISTRY NUMBER : 2169-64-4 BEILSTEIN REFERENCE NO. : 0631776 LAST UPDATED : 199612 DATA ITEMS CITED : 5 MOLECULAR FORMULA : C14-H17-N3-O9 MOLECULAR WEIGHT : 371.34 WISWESSER LINE NOTATION : T6NNVMVJ B- CT5OTJ BOV1 DOV1 E1OV1 COMPOUND DESCRIPTOR : Drug Human SYNONYMS/TRADE NAMES : * Azaribine * 6-Azauridine 2',3',5'-triacetate * CB 304 * NSC-67239 * 2-beta-D-Ribofuranosyl-as-triazine-3,5(2H,4H)-dione 2',3',5'-triacetate * TA-Azur * Triacetyl-6-azauridine * 2',3',5'-Triacetyl-6-azauridine * 2',3',5'-Tri-O-acetyl-6-azauridine * 2-(2',3',5'-Triacetyl-beta-D-ribofuranosyl)-as-triazine-3,5-(2H,4H)-dione * Triazure *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human DOSE/DURATION : 5670 mg/kg/6W TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Blood - changes in cell count (unspecified) REFERENCE : AJOGAH American Journal of Obstetrics and Gynecology. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1920- Volume(issue)/page/year: 108,272,1970 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 12 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 17,511,1970 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 7800 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 17,511,1970 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 321 gm/kg/15W-I TOXIC EFFECTS : Gastrointestinal - hypermotility, diarrhea Blood - changes in erythrocyte (RBC) count Related to Chronic Data - death REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 17,511,1970 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - pig DOSE/DURATION : 30 gm/kg/14W-I TOXIC EFFECTS : Blood - changes in erythrocyte (RBC) count REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 17,511,1970 *** END OF RECORD ***