*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : XY9450000
CHEMICAL NAME : s-Triazine, hexahydro-1,3,5-trinitro-
CAS REGISTRY NUMBER : 121-82-4
BEILSTEIN REFERENCE NO. : 0288466
REFERENCE : 4-26-00-00022 (Beilstein Handbook Reference)
LAST UPDATED : 199712
DATA ITEMS CITED : 40
MOLECULAR FORMULA : C3-H6-N6-O6
MOLECULAR WEIGHT : 222.15
WISWESSER LINE NOTATION : T6N CN ENTJ ANW CNW ENW
COMPOUND DESCRIPTOR : Reproductive Effector
Human
SYNONYMS/TRADE NAMES :
* CX 84A
* Cyclonite
* Cyclotrimethylenenitramine
* Cyclotrimethylenetrinitramine
* Cyklonit
* Esaidro-1,3,5-trinitro-1,3,5-triazina
* Heksogen
* Hexahydro-1,3,5-trinitro-s-triazine
* Hexahydro-1,3,5-trinitro-1,3,5-triazin
* Hexahydro-1,3,5-trinitro-1,3,5-triazine
* Hexogeen
* Hexogen
* Hexogen (Explosive)
* Hexogen 5W
* Hexolite
* KHP 281
* Pbx(AF) 108
* PBXW 108(E)
* PE 4
* RDX
* 1,3,5-Triazine, hexahydro-1,3,5-trinitro-
* Trimethyleentrinitramine
* Trimethylenetrinitramine
* sym-Trimethylenetrinitramine
* Trinitrocyclotrimethylene triamine
* 1,3,5-Trinitrohexahydro-s-triazine
* 1,3,5-Trinitro-1,3,5-triazacyclohexane
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - child
DOSE/DURATION : 85 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270
Madison Ave., New York, NY 10016) V.19- 1982- Volume(issue)/page/year:
24,305,1986
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 100 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
39,531,1977
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 10 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EATR** U.S. Army, Edgewood Arsenal Technical Report. (Aberdeen Proving
Ground, MD 21010) Volume(issue)/page/year: EB-TR-73040
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 18 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EATR** U.S. Army, Edgewood Arsenal Technical Report. (Aberdeen Proving
Ground, MD 21010) Volume(issue)/page/year: EB-TR-73040
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 59 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD-A092-531
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 19 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
EATR** U.S. Army, Edgewood Arsenal Technical Report. (Aberdeen Proving
Ground, MD 21010) Volume(issue)/page/year: EB-TR-73040
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - cat
DOSE/DURATION : 100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see
PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2-
1939- Volume(issue)/page/year: 7,43,1944
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see
PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2-
1939- Volume(issue)/page/year: 7,43,1944
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 25 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EATR** U.S. Army, Edgewood Arsenal Technical Report. (Aberdeen Proving
Ground, MD 21010) Volume(issue)/page/year: EB-TR-73040
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 3600 mg/kg/90D-C
TOXIC EFFECTS :
Cardiac - other changes
Blood - pigmented or nucleated red blood cells
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - transaminases
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD-A092-531
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 28800 mg/kg/90D-C
TOXIC EFFECTS :
Liver - changes in liver weight
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Related to Chronic Data - death
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD-A092-531
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 1800 mg/kg/6W-I
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Gastrointestinal - other changes
Related to Chronic Data - death
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 31,21,1949
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 10 gm/kg
SEX/DURATION : male 13 week(s) pre-mating
female 13 week(s) pre-mating - 22 day(s) after
conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - stillbirth
Reproductive - Effects on Newborn - live birth index (measured after birth)
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD-A092-531
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 3 gm/kg
SEX/DURATION : male 13 week(s) pre-mating
female 13 week(s) pre-mating - 22 day(s) after
conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
gain)
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD-A092-531
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 20 mg/kg
SEX/DURATION : female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD-A166-249
*** REVIEWS ***
ACGIH TLV-Not classifiable as a human carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-TWA 0.5 mg/m3 (skin)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 1.5 mg/m3 (skin)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,221,1971
OSHA PEL (Construc):8H TWA 1.5 mg/m3 (skin)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 1.5 mg/m3 (skin)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 1.5 mg/m3;STEL 3 mg/m3;Skin JAN 1993
OEL-BELGIUM:TWA 1.5 mg/m3;STEL 3 mg/m3;Skin JAN 1993
OEL-DENMARK:TWA 1.5 mg/m3;Skin JAN 1993
OEL-FINLAND:TWA 1.5 mg/m3;STEL 4.5 mg/m3;Skin JAN 1993
OEL-FRANCE:TWA 1.5 mg/m3;Skin JAN 1993
OEL-HUNGARY:TWA 1 mg/m3;STEL 2 mg/m3 JAN 1993
OEL-THE NETHERLANDS:TWA 1.5 mg/m3;Skin JAN 1993
OEL-THE PHILIPPINES:TWA 0.4 mg/m3;Skin JAN 1993
OEL-POLAND:TWA 1 mg/m3 JAN 1993
OEL-RUSSIA:STEL 1 mg/m3 JAN 1993
OEL-SWITZERLAND:TWA 1.5 mg/m3;Skin JAN 1993
OEL-UNITED KINGDOM:TWA 1.5 mg/m3;STEL 3 mg/m3;Skin JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO CYCLONITE-air:10H TWA 1.5 mg/m3;STEL 3 mg/m3 (Sk)
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - M0317
No. of Facilities: 20 (estimated)
No. of Industries: 1
No. of Occupations: 2
No. of Employees: 242 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - M0317
No. of Facilities: 36 (estimated)
No. of Industries: 3
No. of Occupations: 4
No. of Employees: 488 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
*** END OF RECORD ***