*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : XZ2854400 CHEMICAL NAME : s-Triazin-2(1H)-one, 4-amino-1-beta-D-arabinofuranosyl- CAS REGISTRY NUMBER : 65886-71-7 LAST UPDATED : 199206 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C8-H12-N4-O5 MOLECULAR WEIGHT : 244.24 COMPOUND DESCRIPTOR : Drug Mutagen Human SYNONYMS/TRADE NAMES : * 4-Amino-1-beta-D-arabinofuranosyl-s-triazin-3(2H)-one * Ara-AC * 1-beta-D-Arabinofuranosyl-5-azacytosine * 5-Azacytosine arabinoside * Fazarabine * NSC 281272 * 1,3,5-Triazin-2(1H)-one, 4-amino-1-beta-D-arabinofuranosyl- *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Human DOSE/DURATION : 1557 ug/kg/72H-C TOXIC EFFECTS : Gastrointestinal - nausea or vomiting Blood - agranulocytosis REFERENCE : PAACA3 Proceedings of the American Association for Cancer Research. (Waverly Press, 428 E. Preston St., Baltimore, MD 21202) V.1- 1954- Volume(issue)/page/year: 29,194,1988 ** MUTATION DATA ** TYPE OF TEST : DNA inhibition TEST SYSTEM : Human Lymphocyte DOSE/DURATION : 1 umol/L REFERENCE : CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 45,3522,1985 TYPE OF TEST : DNA inhibition TEST SYSTEM : Human Cells - not otherwise specified DOSE/DURATION : 500 nmol/L REFERENCE : BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 42,409,1991 TYPE OF TEST : DNA inhibition TEST SYSTEM : Rodent - mouse Leukocyte DOSE/DURATION : 2 umol/L REFERENCE : PAACA3 Proceedings of the American Association for Cancer Research. (Waverly Press, 428 E. Preston St., Baltimore, MD 21202) V.1- 1954- Volume(issue)/page/year: 24,297,1983 *** END OF RECORD ***