*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : XZ5478300 CHEMICAL NAME : s-Triazolo(5,1-a)isoquinoline, 2-(4-biphenylyl)- CAS REGISTRY NUMBER : 75318-62-6 BEILSTEIN REFERENCE NO. : 5975029 LAST UPDATED : 199612 DATA ITEMS CITED : 10 MOLECULAR FORMULA : C22-H15-N3 MOLECULAR WEIGHT : 321.40 COMPOUND DESCRIPTOR : Reproductive Effector SYNONYMS/TRADE NAMES : * 2-(1,1'-Biphenyl-4-yl)-s-triazole(5,1-a)isoquinoline * 2-(1,1'-Biphenyl-4-yl)-1,2,4-triazole(5,1-a)isoquinoline * 2-(4-Biphenylyl)-s-triazolo(5,1-a)isoquinoline * L 14105 * (1,2,4)Triazolo(5,1-a)isoquinoline, 2-(1,1'-biphenyl)-4-yl- *** HEALTH HAZARD DATA *** ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE : 150 mg/kg SEX/DURATION : female 6-10 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - other measures of fertility REFERENCE : JVPTD9 Journal of Veterinary Pharmacology and Therapeutics. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.1- 1978- Volume(issue)/page/year: 9,246,1986 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE : 2500 ug/kg SEX/DURATION : female 6-10 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - other measures of fertility REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 33,1222,1983 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Rodent - rat DOSE : 2500 ug/kg SEX/DURATION : female 7 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - other measures of fertility REFERENCE : JVPTD9 Journal of Veterinary Pharmacology and Therapeutics. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.1- 1978- Volume(issue)/page/year: 9,246,1986 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - dog DOSE : 35 mg/kg SEX/DURATION : female 18-24 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - other measures of fertility REFERENCE : JVPTD9 Journal of Veterinary Pharmacology and Therapeutics. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.1- 1978- Volume(issue)/page/year: 9,246,1986 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Mammal - dog DOSE : 1 mg/kg SEX/DURATION : female 19 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - other measures of fertility REFERENCE : JVPTD9 Journal of Veterinary Pharmacology and Therapeutics. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.1- 1978- Volume(issue)/page/year: 9,246,1986 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - hamster DOSE : 1250 ug/kg SEX/DURATION : female 4-8 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - other measures of fertility REFERENCE : JVPTD9 Journal of Veterinary Pharmacology and Therapeutics. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.1- 1978- Volume(issue)/page/year: 9,246,1986 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - hamster DOSE : 1 mg/kg SEX/DURATION : female 4-8 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) REFERENCE : JOPHDQ Journal of Pharmacobio-Dynamics. (Japan Pub. Trading Co. (USA), 1255 Howard St., San Francisco, CA 94103) V.1- 1978- Volume(issue)/page/year: 5,55,1982 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - hamster DOSE : 75 ug/kg SEX/DURATION : female 4-8 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - other measures of fertility REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 33,1222,1983 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - hamster DOSE : 80 ug/kg SEX/DURATION : female 4-8 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) REFERENCE : JOPHDQ Journal of Pharmacobio-Dynamics. (Japan Pub. Trading Co. (USA), 1255 Howard St., San Francisco, CA 94103) V.1- 1978- Volume(issue)/page/year: 5,55,1982 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Rodent - hamster DOSE : 50 ug/kg SEX/DURATION : female 4 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - other measures of fertility REFERENCE : JVPTD9 Journal of Veterinary Pharmacology and Therapeutics. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.1- 1978- Volume(issue)/page/year: 9,246,1986 *** END OF RECORD ***