*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : YD1925000
CHEMICAL NAME           : Tricyclo(3.3.1.1(sup 3,7))decan-1-amine
CAS REGISTRY NUMBER     : 768-94-5
BEILSTEIN REFERENCE NO. : 2204333
LAST UPDATED            : 199706
DATA ITEMS CITED        : 8
MOLECULAR FORMULA       : C10-H17-N
MOLECULAR WEIGHT        : 151.28
WISWESSER LINE NOTATION : L66 B6 A B- C 1B ITJ BZ
COMPOUND DESCRIPTOR     : Drug
                          Mutagen
SYNONYMS/TRADE NAMES :
   * 1-Adamantamine
   * 1-Adamantanamine
   * Amantadine
   * 1-Aminoadamantane
   * 1-Aminoadamatane
   * 1-Aminodiamantane
   * 1-Aminotricyclo(3.3.1.1(sup 3,7))decane
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 900 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   JNPHAG Journal de Pharmacologie.  (SPPIF, B.P.22, F-41353 Vineuil, France)
   V.1-    1970-  Volume(issue)/page/year: 9,121,1978
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 223 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BAXXDU British UK Patent Application. (U.S. Patent and Trademark Office,
   Foreign Patents, Washington, DC 20231)  Volume(issue)/page/year: #2070004
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 700 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BAXXDU British UK Patent Application. (U.S. Patent and Trademark Office,
   Foreign Patents, Washington, DC 20231)  Volume(issue)/page/year: #2070004
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 245 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - ataxia
REFERENCE :
   DRFUD4 Drugs of the Future.  (J.R. Prous, S.A., Apartado de Correos 540,
   08080 Barcelona, Spain) V.1-    1975/76-  Volume(issue)/page/year:
   5,557,1980
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Bird - quail
DOSE/DURATION           : >316 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   EESADV Ecotoxicology and Environmental Safety.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802)  V.1-    1977-  Volume(issue)/page/year:
   6,149,1982
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : DNA adduct
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 10 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 89,95,1981

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Negative: Cell transform.-RLV F344 rat embryo
   
   EPA TSCA Section 8(b) CHEMICAL INVENTORY

 
                            *** END OF RECORD ***