*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : YE0700000 CHEMICAL NAME : Triethylamine, 2-chloro- CAS REGISTRY NUMBER : 100-35-6 BEILSTEIN REFERENCE NO. : 0605300 REFERENCE : 4-04-00-00447 (Beilstein Handbook Reference) LAST UPDATED : 199806 DATA ITEMS CITED : 6 MOLECULAR FORMULA : C6-H14-Cl-N MOLECULAR WEIGHT : 135.66 WISWESSER LINE NOTATION : G2N2&2 COMPOUND DESCRIPTOR : Drug Mutagen Primary Irritant SYNONYMS/TRADE NAMES : * N-(2-Chloroethyl)diethylamine * (2-Chloroethyl)diethylamine * beta-Chlorotriethylamine * 2-Chlorotriethylamine * 2-(Diethylamino)chloroethane * Diethylaminoethyl chloride * beta-(Diethylamino)ethyl chloride * N-Diethylaminoethyl chloride * 2-(Diethylamino)ethyl chloride * Diethyl(2-chloroethyl)amine *** HEALTH HAZARD DATA *** ** SKIN/EYE IRRITATION DATA ** TYPE OF TEST : Standard Draize test ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 2 mg/24H REACTION SEVERITY : Severe REFERENCE : 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,608,1986 ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 17 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU. Volume(issue)/page/year: 4,119,1951 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 30 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PHBUA9 Pharmaceutical Bulletin. (Tokyo, Japan) V.1-5, 1953-57. For publisher information, see CPBTAL. Volume(issue)/page/year: 1,297,1953 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 300 uL/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU. Volume(issue)/page/year: 4,119,1951 ** MUTATION DATA ** TYPE OF TEST : DNA inhibition ROUTE OF EXPOSURE : Intravaginal TEST SYSTEM : Rodent - mouse DOSE/DURATION : 5000 ppm REFERENCE : JIDEAE Journal of Investigative Dermatology. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1938- Volume(issue)/page/year: 62,378,1974 *** STATUS IN U.S. *** EPA GENETOX PROGRAM 1988, Positive: Aspergillus-reversion *** END OF RECORD ***