*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : YM4201000
CHEMICAL NAME           : 1-alpha-H,5-alpha-H-Tropan-3-alpha-ol, benzoate
                          (ester), hydrochloride
CAS REGISTRY NUMBER     : 637-23-0
LAST UPDATED            : 198910
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C15-H19-N-O2.Cl-H
MOLECULAR WEIGHT        : 281.81
COMPOUND DESCRIPTOR     : Drug
                          Reproductive Effector
SYNONYMS/TRADE NAMES :
   * 8-Azabicyclo(3.2.1)octan-3-ol, 8-methyl-, benzoate (ester),  
   hydrochloride, exo-
   * Benzoylpseudotropine hydrochloride
   * O-Benzoyltropine hydrochloride
   * Pseudotropine benzoate hydrochloride
   * Tropacaine hydrochloride
   * Tropacocaine hydrochloride
   * Tropacocain hydrochloride
   * Tropakokain hydrochlorid
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 350 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
   QJPPAL Quarterly Journal of Pharmacy & Pharmacology.  (London, UK)  V.2-21,
   1929-48.  For publisher information, see JPPMAB.  Volume(issue)/page/year:
   7,227,1934
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 465 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   RCSADO Research Communications in Substances Abuse.  (PJD Pub. Ltd., P.O.Box
   966, Westbury, NY 11590) V.1-    1980-  Volume(issue)/page/year: 5,279,1984
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 42 mg/kg
TOXIC EFFECTS :
   Behavioral - general anesthetic
REFERENCE :
   WDMU** "Vergleichend-pharmakologische Untersuchungen ueber die haemolytische
   Wirkung und die Toxizitat der Lokalanaesthetika, Dissertation," Walther, M.,
   Pharmakologischen Instit Martin Luther-Universitat Halle-Wittenburg, Ger.
   Dem. Rep., 1936 Volume(issue)/page/year: -,-,1936
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 120 mg/kg
SEX/DURATION            : female 7 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - Central Nervous System
REFERENCE :
   RCSADO Research Communications in Substances Abuse.  (PJD Pub. Ltd., P.O.Box
   966, Westbury, NY 11590) V.1-    1980-  Volume(issue)/page/year: 5,279,1984
 
                            *** END OF RECORD ***