*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : YM4375200
CHEMICAL NAME           : 1-alpha-H,5-alpha-H-Tropan-3-alpha-ol,
                          2-(p-chlorophenyl)-2-phenylacetate, hydrochloride
CAS REGISTRY NUMBER     : 74051-40-4
LAST UPDATED            : 199012
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C22-H24-Cl-N-O2.Cl-H
MOLECULAR WEIGHT        : 406.38
WISWESSER LINE NOTATION : T56 A ANTJ A1 CR DG& DOV1R &GH
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Acetic acid, (p-chlorophenyl)phenyl-, tropan-3-yl ester hydrochloride
   * p-Chlorodiphenylacetyltropeine hydrochloride
   * Chlorotropacin, hydrochloride
   * DF 303
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 310 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - convulsions or effect on seizure threshold
   Kidney, Ureter, Bladder - hematuria
REFERENCE :
   BJPCAL British Journal of Pharmacology and Chemotherapy.  (London, UK)
   V.1-33, 1946-68.  For publisher information, see BJPCBM.
   Volume(issue)/page/year: 14,559,1959
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 48 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   RPTOAN Russian Pharmacology and Toxicology (English Translation).
   Translation of FATOAO.  (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey,
   UK)  V.30-    1967-  Volume(issue)/page/year: 36,16,1973
 
                            *** END OF RECORD ***