*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : YM3550000
CHEMICAL NAME           : 1-alpha-H,5-alpha-H-Tropanium,
                          8-(p-chlorobenzyl)-3-hydroxy-, bromide,
                          p-aminobenzilate (ester)
CAS REGISTRY NUMBER     : 63977-81-1
LAST UPDATED            : 199109
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C22-H26-Cl-N2-O2.Br
MOLECULAR WEIGHT        : 465.86
WISWESSER LINE NOTATION : T56 A AKTJ A1 A1R DG& GOVXQR&R DZ &Q &E
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * p-Chlorobenzyl-p-aminobenzoyltropinium bromide
   * N-266
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2500 ug/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - spastic paralysis with or without sensory
   change
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   APACAB Acta Physiologica Academiae Scientiarum Hungaricae.  (Budapest,
   Hungary)  V.1-60, 1950-82.  Volume(issue)/page/year: 4,341,1953
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 35 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   32ZCAI "Ganglion-Blocking and Ganglion-Stimulation Agents," Kharkevich,
   D.A., Moscow, First Moscow Medical Institute, 1967 Volume(issue)/page/year:
   -,71,1967
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - cat
DOSE/DURATION           : 5 mg/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - spastic paralysis with or without sensory
   change
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   APACAB Acta Physiologica Academiae Scientiarum Hungaricae.  (Budapest,
   Hungary)  V.1-60, 1950-82.  Volume(issue)/page/year: 4,341,1953
 
                            *** END OF RECORD ***