*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : YM6107000
CHEMICAL NAME           : 1-alpha-H,5-alpha-H-Tropan-3-alpha-ol, (-)-tropate
                          (ester), sulfate (2:1)
CAS REGISTRY NUMBER     : 620-61-1
LAST UPDATED            : 199712
DATA ITEMS CITED        : 7
MOLECULAR FORMULA       : C34-H46-N2-O6.H2-O4-S
MOLECULAR WEIGHT        : 676.90
COMPOUND DESCRIPTOR     : Drug
                          Human
SYNONYMS/TRADE NAMES :
   * Egazil
   * Hyoscyamine sulfate
   * (-)-Hyoscyamine sulfate
   * Levsinex
   * Levsin sulfate
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - infant
DOSE/DURATION           : 400 uL/kg/1D-I
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
   Cardiac - pulse rate increase, without fall in BP
   Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
   AJEMEN American Journal of Emergency Medicine.  (WB Saunders, Philadelphia,
   PA)  V.1-    1983-  Volume(issue)/page/year: 15,532,1997
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - infant
DOSE/DURATION           : 800 uL/kg/1D-I
TOXIC EFFECTS :
   Behavioral - irritability
   Cardiac - pulse rate increase, without fall in BP
   Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
   AJEMEN American Journal of Emergency Medicine.  (WB Saunders, Philadelphia,
   PA)  V.1-    1983-  Volume(issue)/page/year: 15,532,1997
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - infant
DOSE/DURATION           : 400 uL/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Cardiac - pulse rate increase, without fall in BP
   Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
   AJEMEN American Journal of Emergency Medicine.  (WB Saunders, Philadelphia,
   PA)  V.1-    1983-  Volume(issue)/page/year: 15,532,1997
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 210 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPMSAE Journal of Pharmaceutical Sciences.  (American Pharmaceutical Assoc.,
   2215 Constitution Ave., NW, Washington, DC 20037)  V.50-    1961-
   Volume(issue)/page/year: 55,849,1966

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - 80431
       No. of Facilities: 967 (estimated)
       No. of Industries: 3
       No. of Occupations: 9
       No. of Employees: 3990 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - 80431
       No. of Facilities: 445 (estimated)
       No. of Industries: 1
       No. of Occupations: 5
       No. of Employees: 14970 (estimated)
       No. of Female Employees: 12609 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY

 
                            *** END OF RECORD ***