*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : YP0175000
CHEMICAL NAME           : Tylocrebrine
CAS REGISTRY NUMBER     : 6879-02-3
BEILSTEIN REFERENCE NO. : 1555044
LAST UPDATED            : 199612
DATA ITEMS CITED        : 6
MOLECULAR FORMULA       : C24-H27-N-O4
MOLECULAR WEIGHT        : 393.52
WISWESSER LINE NOTATION : T D5 B6 K666 DNJ MO1 NO1 RO1 SO1
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Dibenzo(f,h)pyrrolo(1,2-b)isoquinoline,  
   9,11,12,13,13a,14-hexahydro-2,3,5,6-tetramethoxy-
   * NSC-60387
   * (-)-Tylocrebrine
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 65 mg/kg
TOXIC EFFECTS :
   Behavioral - changes in motor activity (specific assay)
   Gastrointestinal - hypermotility, diarrhea
   Skin and Appendages - hair
REFERENCE :
   NCICP* Progress Report Submitted to the National Cancer Institute by Charles
   Pfizer & Co.  Volume(issue)/page/year: -,77,1964
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 32 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - ataxia
   Gastrointestinal - hypermotility, diarrhea
REFERENCE :
   NCICP* Progress Report Submitted to the National Cancer Institute by Charles
   Pfizer & Co.  Volume(issue)/page/year: -,77,1964
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 50 mg/kg
TOXIC EFFECTS :
   Behavioral - changes in motor activity (specific assay)
   Behavioral - ataxia
   Gastrointestinal - hypermotility, diarrhea
REFERENCE :
   NCICP* Progress Report Submitted to the National Cancer Institute by Charles
   Pfizer & Co.  Volume(issue)/page/year: -,77,1964
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 42 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - ataxia
REFERENCE :
   NCICP* Progress Report Submitted to the National Cancer Institute by Charles
   Pfizer & Co.  Volume(issue)/page/year: -,77,1964
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 12 mg/kg/24D-I
TOXIC EFFECTS :
   Gastrointestinal - changes in structure or function of esophagus
   Gastrointestinal - ulceration or bleeding from large intestine
   Blood - other changes
REFERENCE :
   NCICP* Progress Report Submitted to the National Cancer Institute by Charles
   Pfizer & Co.  Volume(issue)/page/year: -,77,1964
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Primate - monkey
DOSE/DURATION           : 24 mg/kg/24D-I
TOXIC EFFECTS :
   Liver - other changes
   Blood - pigmented or nucleated red blood cells
   Blood - changes in erythrocyte (RBC) count
REFERENCE :
   NCICP* Progress Report Submitted to the National Cancer Institute by Charles
   Pfizer & Co.  Volume(issue)/page/year: -,77,1964
 
                            *** END OF RECORD ***