*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : YP0875000
CHEMICAL NAME           : Tylosin, tartrate
CAS REGISTRY NUMBER     : 1405-54-5
LAST UPDATED            : 199806
DATA ITEMS CITED        : 12
MOLECULAR FORMULA       : C45-H77-N-O17.C4-H6-O6
MOLECULAR WEIGHT        : 1054.33
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Pharmasin
   * Tylosin, (R-(R*,R*)-2,3-dihydroxybutanedioate) (salt)
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >6200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AAGAAW Antimicrobial Agents Annual.  (New York, NY)  1960.  For publisher
   information, see AMACCQ.  Volume(issue)/page/year: -,595,1960
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 695 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   FCTXAV Food and Cosmetics Toxicology.  (London, UK)  V.1-19, 1963-81.  For
   publisher information, see FCTOD7.  Volume(issue)/page/year: 4,1,1966
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >6200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AAGAAW Antimicrobial Agents Annual.  (New York, NY)  1960.  For publisher
   information, see AMACCQ.  Volume(issue)/page/year: -,595,1960
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1354 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   FCTXAV Food and Cosmetics Toxicology.  (London, UK)  V.1-19, 1963-81.  For
   publisher information, see FCTOD7.  Volume(issue)/page/year: 4,1,1966
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 589 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   FCTXAV Food and Cosmetics Toxicology.  (London, UK)  V.1-19, 1963-81.  For
   publisher information, see FCTOD7.  Volume(issue)/page/year: 4,1,1966
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : >1 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AAGAAW Antimicrobial Agents Annual.  (New York, NY)  1960.  For publisher
   information, see AMACCQ.  Volume(issue)/page/year: -,595,1960
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Bird - chicken
DOSE/DURATION           : 5400 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AAGAAW Antimicrobial Agents Annual.  (New York, NY)  1960.  For publisher
   information, see AMACCQ.  Volume(issue)/page/year: -,595,1960
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Bird - chicken
DOSE/DURATION           : 620 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - food intake (animal)
   Behavioral - irritability
REFERENCE :
   VMDNAV Veterinarno-Meditsinski Nauki.  Veterinary Science.  (Hemus, Blvd.
   Russki 6, Sofia, Bulgaria) V.1-    1964-  Volume(issue)/page/year:
   15,52,1978
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Bird - chicken
DOSE/DURATION           : 48 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - food intake (animal)
   Behavioral - irritability
REFERENCE :
   VMDNAV Veterinarno-Meditsinski Nauki.  Veterinary Science.  (Hemus, Blvd.
   Russki 6, Sofia, Bulgaria) V.1-    1964-  Volume(issue)/page/year:
   15,52,1978
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Bird - chicken
DOSE/DURATION           : 432 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AAGAAW Antimicrobial Agents Annual.  (New York, NY)  1960.  For publisher
   information, see AMACCQ.  Volume(issue)/page/year: -,595,1960
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Bird - chicken
DOSE/DURATION           : 5400 mg/kg/6W-I
TOXIC EFFECTS :
   Blood - other changes
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
   Biochemical - Enzyme inhibition, induction, or change in blood or tissue
   levels - transaminases
REFERENCE :
   VMDNAV Veterinarno-Meditsinski Nauki.  Veterinary Science.  (Hemus, Blvd.
   Russki 6, Sofia, Bulgaria) V.1-    1964-  Volume(issue)/page/year:
   15,52,1978

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - M2751
       No. of Facilities: 33 (estimated)
       No. of Industries: 1
       No. of Occupations: 1
       No. of Employees: 99 (estimated)

 
                            *** END OF RECORD ***