*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : YM3751600
CHEMICAL NAME           : 1-alpha-H,5-alpha-H-Tropanium,
                          3-alpha-hydroxy-8-methyl, p-tolylacetate (ester),
                          iodide
CAS REGISTRY NUMBER     : 5135-79-5
LAST UPDATED            : 199712
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C18-H26-N-O2.I
MOLECULAR WEIGHT        : 415.35
WISWESSER LINE NOTATION : T56 A AKTJ A1 A1 GOV1R D1 &I
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * 8-Azoniabicyclo (3.2.1)octane, 8,8-dimethyl-3-((4-methylbenzoyl)oxy)-,  
   iodide, endo-
   * 8-Methyltropinium iodide, p-tolyl acetate
   * Tropine p-tolylacetate methiodide
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 28 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - changes in motor activity (specific assay)
   Lungs, Thorax, or Respiration - respiratory obstruction
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   9,240,1966
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - cat
DOSE/DURATION           : 20 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - rigidity (including catalepsy)
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   9,240,1966
 
                            *** END OF RECORD ***